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Table 2 Comparison of characteristics of patients in short-term (ST) group at baseline and after 6 months of withdrawal

From: Effects of metformin withdrawal after long and short term treatment in PCOS: observational longitudinal study

 

Baseline

After 6 months

p

Body weight (kg)

92 (75.5–107.3)

93.9 ± 23.7

96 (76–116)

98 ± 25.3

0.019

BMI (kg/m2)

32.7 (26.9–34.7)

33.7 ± 9.5

33.3 (26.6–39.7)

35.2 ± 10.2

0.023

Waist circumference (cm)

106.5 (92–119.8)

107 (89.5–118.5)

0.722

Systolic blood pressure (mmHg)

124.5 (113.8–130)

123 (113.5–137.5)

0.688

Diastolic blood pressure (mmHg)

84.5 (80–98.5)

84 (80–103.5)

0.118

No. of menstrual bleeding in last 6 month

6 (4.3–6)

6 (4.5–6)

0.715

TFEQ-R18: cognitive restraint (%)

61.1 (50.0–66.7)

61.1 (45.8–84.7)

0.682

TFEQ-R18: emotional eating (%)

22.2 (0.0–77.8)

22.2 (13.9–52.8)

0.319

TFEQ-R18: uncontrolled eating (%)

22.2 (3.7–40.7)

33.3 (10.2–40.7)

0.034

Total cholesterol (nmol/L)

4.7 (3.3–5.5)

4.6 (3.1–6.1)

0.562

HDL (mmol/L)

1.4 (1.1–1.5)

1.4 (1.1–1.7)

0.474

LDL (mmol/L)

2.4 (1.6–3.5)

2.1 (1.6–3.6)

0.858

TG (mmol/L)

1.2 (0.8–1.7)

1.4 (0.8–2)

0.723

FSH (IU/L)

4.7 (2.9–6.4)

5.2 (3.3–6.2)

1.000

LH (IU/L)

7.7 (5.4–9.5)

9.5 (5.3–16.2)

0.328

SHBG (nmol/L)

31.8 (22–68.2)

32.6 (20.4–75.7)

0.552

Total testosterone (nmol/L)

1.02 (0.69–1.58)

0.83 (0.69–1.5)

0.110

FAI score (%)

3 (2–4)

3 (1–4)

0.473

Free testosterone (pmol/L)

6.5 (5.9–8.4)

5.8 (4.9–7.2)

0.382

Androstenedione (nmol/L)

5.4 (4.3–7)

6.8 (4.6–9.9)

0.075

Glucose OGTT 0 (mmol/L)

5.3 (4.9–5.6)

4.9 (4.5–5.5)

0.021

Glucose OGTT 120 (mmol/L)

5.8 (5.1–8.1)

5.5 (4.2–7.3)

0.506

Insulin OGTT 0 (mU/L)

0.7 (0.6–1.3)

0.8 (0.5–1.4)

0.239

Insulin OGTT 120 (mU/L)

69 (42.3–124.3)

66.5 (37.2–174.5)

0.249

HOMA-IR score

2.5 (1.4–4.9)

1.7 (0.5–4.9)

0.221