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Table 1 Comparison of characteristics of patients in short-term (ST) and long-term (LT) group 6 months after withdrawal

From: Effects of metformin withdrawal after long and short term treatment in PCOS: observational longitudinal study

 

ST group

N = 20

LT group

N = 20

p

Age (years)

31 (28.3–35.5)

32 (26–40)

0.770

Body weight (kg)

96 (76–116)

87 (73–105)

0.586

BMI (kg/m2)

33.3 (26.6–39.7)

32.5 (28.1–37.8)

0.964

Waist circumference (cm)

107 (89.5–118.5)

102 (90–113)

0.440

Systolic blood pressure (mmHg)

123 (113.5–137.5)

118 (111–122)

0.170

Diastolic blood pressure (mmHg)

84 (80–103.5)

85 (74–86)

0.142

No. of menstrual bleeding in last 6 month

6 (4.5–6)

6 (4–6)

0.586

TFEQ-R18: cognitive restraint (%)

61.1 (45.8–84.7)

47.2 (37.5–61.1)

0.085

TFEQ-R18: emotional eating (%)

22.2 (13.9–52.8)

33.3 (11.1–58.3)

0.631

TFEQ-R18: uncontrolled eating (%)

33.3 (10.2–40.7)

29.6 (18.5–42.6)

0.631

Total cholesterol (nmol/L)

4.6 (3.1–6.1)

4.9 (4.3–5.2)

0.786

HDL (mmol/L)

1.4 (1.1–1.7)

1.6 (1.2–1.7)

0.496

LDL (mmol/L)

2.1 (1.6–3.6)

2.5 (2.1–3.1)

0.339

TG (mmol/L)

1.4 (0.8–2)

1.3 (0.8–1.9)

0.964

FSH (IU/L)

5.2 (3.3–6.2)

5.4 (3.2–6.3)

0.683

LH (IU/L)

9.5 (5.3–16.2)

6.1 (2.8–8.4)

0.130

SHBG (nmol/L)

32.6 (20.4–75.7)

39.7 (32.5–56.5)

0.458

Total testosterone (nmol/L)

0.83 (0.69–1.5)

0.73 (0.69–1.36)

0.618

FAI score (%)

3 (1–4)

2 (2–3)

0.440

Free testosterone (pmol/L)

5.8 (4.9–7.2)

6.9 (4.8–7.5)

0.496

Androstenedione (nmol/L)

6.8 (4.6–9.9)

7.8 (4.8–9.6)

0.683

Glucose OGTT 0 (mmol/L)

4.9 (4.5–5.5)

5.3 (4.7–5.6)

0.316

Glucose OGTT 120 (mmol/L)

5.5 (4.2–7.3)

5.4 (4–6.5)

0.586

Insulin OGTT 0 (mU/L)

8.8 (2.3–21.9)

6.6 (2.6–12.9)

0.586

Insulin OGTT 120 (mU/L)

66.5 (37.2–174.5) [3]

45.7 (43.1–81.3)

0.170

HOMA-IR score

1.7 (0.5–4.9)

1.6 (0.5–2.7)

0.786