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Table 2 Characterization of the experimental design of the evaluated studies

From: Diet-induced obesity in animal models: points to consider and influence on metabolic markers

Article ID

Obesogenic diet

Control diet

Diet offering method

Intervention time

Animals

Type

%

kcal/g

Type

%

kcal/g

Type

Sex

Weeks-old

Asokan et al. 2018 [56]

High-fat

60.0 fat

Standard

Ad libitum

10 weeks

C57BL/6J mice

Male

6

Bortolin et al. 2018 [8]

High fat

60.0 fat

Control

Ad libitum

18 weeks

Wistar rats

Male

8

Western

42.5 fat

Heo et al. 2018 [2]

High-fat

60.0 fat, 20.0 carb., 20.0 protein

Low-fat

10.0 fat, 70.0 carb., 20.0 protein

Free access

10 weeks

Sprague–Dawley rats

Male

5

Hira et al. 2018 [24]

High-fat high-sucrose ▪

30.0 fat, 40.0 sucrose

5.1

Control

(AIN-93G)

4.0

Free access

8 days

Sprague–Dawley rats

Male

5

8 weeks

Lee et al. 2018 [27]

High-fat

B-MLCT ▪

30.0 fat

5.5

Low-fat

B-MLCT ▪

7.0 fat

4.0

Ad libitum

16 weeks

C57BL/6J mice

Male

6

High-fat

E-MLCT ▪

Low-fat

E-MLCT ▪

High-fat

C-MLCT ▪

Low-fat

C-MLCT ▪

Iñiguez et al. 2018 [25]

High-fat

60.0 fat

Control

Pair-feeding

10 weeks

C57BL/6J mice

Male

8

Kazeminasab et al. 2018 [12]

High-fat

45.0 fat, 35.0 carb., 20.0 protein

Low-fat

10.0 fat, 70.0 carb., 20.0 protein

Ad libitum

12 weeks

C57BL/6J mice

Male

6

Matias et al. 2018 [3]

High-sugar

25.9 fat, 52.3 carb., 24.8 protein

3.6

Control

25.6 fat, 52.3 carb., 21.8 protein

3.5

Free access

20 weeks

Wistar rats

Male

4

High-fat

37.6 fat, 44.6 carb., 17.8 protein

4.6

High-fat/ high-sugar

37.4 fat, 43.4 carb., 19.2 protein

4.5

Miranda et al. 2018 [19]

High-fat

4.6

Control

-

3.7

Free access

6 weeks

Sprague–Dawley rats

Male

-

Wistar rats

Male

-

Rocha Rodrigues et al. 2018 [57]

High-fat

71.0 fat, 11.0 carb., 18.0 protein

Standard

35.0 fat, 47.0 carb., 18.0 protein

-

Pair-fed

17 weeks

Sprague–Dawley rats

Male

6

Son et al. 2018 [21]

High-fat

Normal

(AIN-93)

Ad libitum

8 weeks

Sprague–Dawley rats

Male

5

Virto et al. 2018 [62]

High-fat

35.2 fat, 35.5 carb., 20.4 protein

5.4

Control

3.0 fat, 60.0 carb., 16.0 protein

2.9

Ad libitum

26 weeks

Wistar rats

Wu et al. 2018 [30]

High-fat

23.7 fat, 53.3 carb., 23.0 protein

5.1

Normal

13.3 saturated fat, 60.5 carb., 26.2 protein

3.6

Ad libitum

6 weeks

C57BL/6 mice

Male

6

Yuan et al. 2018 [35]

High fat

45.0 fat, 35.0 carb., 20.0 protein

Normal

4.0 fat, 62.0 carb., 18.0 protein

 -

Ad libitum

18 weeks

C57BL/6J mice

Male

7

24 weeks

Aslani et al. 2017 [63]

High-fat

42.0 fat, 39.0 carb., 19.0 protein

Normal

11.0 fat, 61.0 carb., 28.0 protein

Ad libitum

12 weeks

Wistar rats

Male

8

Blancas-Velazquez et al.2017 [15]

High-fat high-sugar

Control

12.0 fat, 65.0 carb., 23.0 protein

2.8

Ad libitum

6 weeks

C57BL/6J mice

Male

6–8

Karimi et al. 2017 [18]

High-fat (AIN-76A)

5.5

Standard

3.8

Ad libitum

12 weeks

Sprague–Dawley rats

Male

6

27 weeks

Kim et al. 2017 [33]

High-fat

60.0 fat

Standard

12.0 fat, 64.0 carb., 24.0 protein

Ad libitum

6 weeks

C57BL/6 mice

Male

4

Kus et al. 2017 [68]

High-fat

60.0 fat

Control

(AIN-93G)

15 weeks

C57BL/6 mice

Male

La Frano et al. 2017 [26]

High-fat high-cholesterol

60.0 fat

5.2

Low-fat low-cholesterol

10.0 fat

3.8

Ad libitum

18 weeks

C57BL/6J mice

Male

12

Pan et al. 2017 [61]

High-fat

45.0 fat

Normal

15.0 fat

Free access

16 weeks

C57BL/6J mice

Male

4

Picklo et al. 2017 [10]

High-fat oleic

50.0 fat, 30.0 carb., 20.0 protein

5.5

Low fat

16.0 fat, 64.0 carb., 20.0 protein

4.3

8 weeks

C57BL/6 mice

Male

12

High-fat saturated

Yang et al. 2017 [22]

High-fat

Control

6 weeks

Sprague–Dawley rats

Choi et al. 2016 [9]

High-fat

40.0 fat

Normal

(AIN-76)

11.5 fat

12 weeks

C57BL/6J mice

Male

8

Jambocus et al. 2016 [17]

High-saturated fat

Normal

Ad libitum

12 weeks

Sprague–Dawley rats

Male

3

Krishna et al. 2016 [1]

High-fat

41.0 fat, 40.0 carb., 19.0 protein

Standard

11.0 fat, 65.0 carb., 19.0 protein

Ad libitum

14 weeks

C57BL/6J mice

Male

3

Naidu et al. 2016 [20]

High-fat

Normal (AIN-93)

30 days

Wistar rats

Male

-

Zhao et al. 2016 [64]

High-fat

45.0 fat, 36.0 carb., 19.0 protein

Control

12.0 fat, 60.5 carb., 27.5 protein

8 weeks

Sprague–Dawley rats

Male

-

Huang et al. 2015 [16]

High-fat

Normal

Ad libitum

12 weeks

Sprague–Dawley rats

Male

Li et al. 2015 [51]

High-fat

45.0 fat

Control

10.0 fat

Ad libitum

22 weeks

C57BL/6J mice

Female

6–8

Nam et al. 2015 [28]

High-fat

45.2 fat, 38.0 carb., 16.8 protein

4.7

Low-fat

11.7 fat, 67.5 carb., 20.8 protein

3.8

Ad libitum

11 weeks

C57BL/6J mice

Male

4

Rodríguez- Rodríguez et al. 2015 [29]

High-fat

45.2 fat, 34.2 carb., 20.6 protein

Control

12.0 fat, 67.4 carb., 20.6 protein

Free access

12 weeks

C57BL/6NCrl mice

Male

8

Savetsky et al. 2015 [34]

High-fat

60.0 fat

Normal

13.0 fat

Ad libitum

10–12 weeks

C57BL/6J mice

Male

6

Wyatt et al. 2015 [13]

High-fat

60.0 fat

Control

10.0 fat

5 weeks

C57BL/6J mice

Male

6

8 weeks

Zhang et al. 2015 [23]

High-fat

Normal (AIN-93 M)

Ad libitum

16 weeks

C57BL/6 mice

Male

5

  1. , % g/kg; ▪, % w/w; , % kcal; , % g/100 g; , Not determine the unit of %; B-MLCT, Non-enzymatically interesterified MLCT; E-MLCT, Enzymatically interesterified MCLT; C-MLCT, Commercially MLCT; carb., carbohydrate