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Table 2 Characterization of the experimental design of the evaluated studies

From: Diet-induced obesity in animal models: points to consider and influence on metabolic markers

Article ID Obesogenic diet Control diet Diet offering method Intervention time Animals
Type % kcal/g Type % kcal/g Type Sex Weeks-old
Asokan et al. 2018 [56] High-fat 60.0 fat Standard Ad libitum 10 weeks C57BL/6J mice Male 6
Bortolin et al. 2018 [8] High fat 60.0 fat Control Ad libitum 18 weeks Wistar rats Male 8
Western 42.5 fat
Heo et al. 2018 [2] High-fat 60.0 fat, 20.0 carb., 20.0 protein Low-fat 10.0 fat, 70.0 carb., 20.0 protein Free access 10 weeks Sprague–Dawley rats Male 5
Hira et al. 2018 [24] High-fat high-sucrose ▪ 30.0 fat, 40.0 sucrose 5.1 Control
(AIN-93G)
4.0 Free access 8 days Sprague–Dawley rats Male 5
8 weeks
Lee et al. 2018 [27] High-fat
B-MLCT ▪
30.0 fat 5.5 Low-fat
B-MLCT ▪
7.0 fat 4.0 Ad libitum 16 weeks C57BL/6J mice Male 6
High-fat
E-MLCT ▪
Low-fat
E-MLCT ▪
High-fat
C-MLCT ▪
Low-fat
C-MLCT ▪
Iñiguez et al. 2018 [25] High-fat 60.0 fat Control Pair-feeding 10 weeks C57BL/6J mice Male 8
Kazeminasab et al. 2018 [12] High-fat 45.0 fat, 35.0 carb., 20.0 protein Low-fat 10.0 fat, 70.0 carb., 20.0 protein Ad libitum 12 weeks C57BL/6J mice Male 6
Matias et al. 2018 [3] High-sugar 25.9 fat, 52.3 carb., 24.8 protein 3.6 Control 25.6 fat, 52.3 carb., 21.8 protein 3.5 Free access 20 weeks Wistar rats Male 4
High-fat 37.6 fat, 44.6 carb., 17.8 protein 4.6
High-fat/ high-sugar 37.4 fat, 43.4 carb., 19.2 protein 4.5
Miranda et al. 2018 [19] High-fat 4.6 Control - 3.7 Free access 6 weeks Sprague–Dawley rats Male -
Wistar rats Male -
Rocha Rodrigues et al. 2018 [57] High-fat 71.0 fat, 11.0 carb., 18.0 protein Standard 35.0 fat, 47.0 carb., 18.0 protein - Pair-fed 17 weeks Sprague–Dawley rats Male 6
Son et al. 2018 [21] High-fat Normal
(AIN-93)
Ad libitum 8 weeks Sprague–Dawley rats Male 5
Virto et al. 2018 [62] High-fat 35.2 fat, 35.5 carb., 20.4 protein 5.4 Control 3.0 fat, 60.0 carb., 16.0 protein 2.9 Ad libitum 26 weeks Wistar rats
Wu et al. 2018 [30] High-fat 23.7 fat, 53.3 carb., 23.0 protein 5.1 Normal 13.3 saturated fat, 60.5 carb., 26.2 protein 3.6 Ad libitum 6 weeks C57BL/6 mice Male 6
Yuan et al. 2018 [35] High fat 45.0 fat, 35.0 carb., 20.0 protein Normal 4.0 fat, 62.0 carb., 18.0 protein  - Ad libitum 18 weeks C57BL/6J mice Male 7
24 weeks
Aslani et al. 2017 [63] High-fat 42.0 fat, 39.0 carb., 19.0 protein Normal 11.0 fat, 61.0 carb., 28.0 protein Ad libitum 12 weeks Wistar rats Male 8
Blancas-Velazquez et al.2017 [15] High-fat high-sugar Control 12.0 fat, 65.0 carb., 23.0 protein 2.8 Ad libitum 6 weeks C57BL/6J mice Male 6–8
Karimi et al. 2017 [18] High-fat (AIN-76A) 5.5 Standard 3.8 Ad libitum 12 weeks Sprague–Dawley rats Male 6
27 weeks
Kim et al. 2017 [33] High-fat 60.0 fat Standard 12.0 fat, 64.0 carb., 24.0 protein Ad libitum 6 weeks C57BL/6 mice Male 4
Kus et al. 2017 [68] High-fat 60.0 fat Control
(AIN-93G)
15 weeks C57BL/6 mice Male
La Frano et al. 2017 [26] High-fat high-cholesterol 60.0 fat 5.2 Low-fat low-cholesterol 10.0 fat 3.8 Ad libitum 18 weeks C57BL/6J mice Male 12
Pan et al. 2017 [61] High-fat 45.0 fat Normal 15.0 fat Free access 16 weeks C57BL/6J mice Male 4
Picklo et al. 2017 [10] High-fat oleic 50.0 fat, 30.0 carb., 20.0 protein 5.5 Low fat 16.0 fat, 64.0 carb., 20.0 protein 4.3 8 weeks C57BL/6 mice Male 12
High-fat saturated
Yang et al. 2017 [22] High-fat Control 6 weeks Sprague–Dawley rats
Choi et al. 2016 [9] High-fat 40.0 fat Normal
(AIN-76)
11.5 fat 12 weeks C57BL/6J mice Male 8
Jambocus et al. 2016 [17] High-saturated fat Normal Ad libitum 12 weeks Sprague–Dawley rats Male 3
Krishna et al. 2016 [1] High-fat 41.0 fat, 40.0 carb., 19.0 protein Standard 11.0 fat, 65.0 carb., 19.0 protein Ad libitum 14 weeks C57BL/6J mice Male 3
Naidu et al. 2016 [20] High-fat Normal (AIN-93) 30 days Wistar rats Male -
Zhao et al. 2016 [64] High-fat 45.0 fat, 36.0 carb., 19.0 protein Control 12.0 fat, 60.5 carb., 27.5 protein 8 weeks Sprague–Dawley rats Male -
Huang et al. 2015 [16] High-fat Normal Ad libitum 12 weeks Sprague–Dawley rats Male
Li et al. 2015 [51] High-fat 45.0 fat Control 10.0 fat Ad libitum 22 weeks C57BL/6J mice Female 6–8
Nam et al. 2015 [28] High-fat 45.2 fat, 38.0 carb., 16.8 protein 4.7 Low-fat 11.7 fat, 67.5 carb., 20.8 protein 3.8 Ad libitum 11 weeks C57BL/6J mice Male 4
Rodríguez- Rodríguez et al. 2015 [29] High-fat 45.2 fat, 34.2 carb., 20.6 protein Control 12.0 fat, 67.4 carb., 20.6 protein Free access 12 weeks C57BL/6NCrl mice Male 8
Savetsky et al. 2015 [34] High-fat 60.0 fat Normal 13.0 fat Ad libitum 10–12 weeks C57BL/6J mice Male 6
Wyatt et al. 2015 [13] High-fat 60.0 fat Control 10.0 fat 5 weeks C57BL/6J mice Male 6
8 weeks
Zhang et al. 2015 [23] High-fat Normal (AIN-93 M) Ad libitum 16 weeks C57BL/6 mice Male 5
  1. , % g/kg; ▪, % w/w; , % kcal; , % g/100 g; , Not determine the unit of %; B-MLCT, Non-enzymatically interesterified MLCT; E-MLCT, Enzymatically interesterified MCLT; C-MLCT, Commercially MLCT; carb., carbohydrate