Fig. 3From: Diabetes, obesity, and insulin resistance in COVID-19: molecular interrelationship and therapeutic implicationsDysregulation of the RAAS. ACE2 cleaves AI and AII into inactive angiotensin 1–9 and angiotensin 1–7, respectively, and the later has vasodilator and antifibrotic effects, but SARS-CoV binds and downregulates the expression of ACE2, which is associated with the unopposed AII actionBack to article page