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Table 2 Association of GCKR SNPs with MetS and qualitative MetS components in an additive genetic model

From: GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

Categorical traits rs780094 OR (CI) model 1 Adjusted OR (CI) model 2 rs780093 OR (CI) model 1 Adjusted OR (CI) model 2 rs1260326 OR (CI) model 1 Adjusted OR (CI) model 2
Metabolic syndrome CC (reference) 1 1 CC (reference) 1 1 CC (reference) 1 1
CT 1.2 (1.06–1.36)* 1.22 (1.05–1.41)* CT 1.11 (0.99–1.26) 1.14 (0.99–1.32) CT 1.17 (1.04–1.33)* 1.19 (1.03–1.38)*
TT 1.3 (1.12–1.51)* 1.28 (1.08–1.53)* TT 1.32 (1.14–1.53)* 1.34 (1.13–1.6)* TT 1.29 (1.11–1.49)* 1.28 (1.08–1.53)*
High waist circumference CC (reference) 1 1 CC (reference) 1 1 CC (reference) 1 1
CT 1.12 (0.99–1.27) 1.09 (0.95–1.25) CT 1.08 (0.95–1.22) 1.08 (0.94–1.24) CT 1.1 (0.97–1.25) 1.08 (0.94–1.24)
TT 1.18 (1.02–1.38)* 1.13 (0.96–1.34) TT 1.2 (1.03–1.4)* 1.17 (0.99–1.39) TT 1.2 (1.03–1.4)* 1.17 (0.99–1.38)
Low HDL-C CC (reference) 1 1 CC (reference) 1 1 CC (reference) 1 1
CT 1.26 (1.1–1.44)* 1.25 (1.09–1.43)* CT 1.21 (1.06–1.38)* 1.2 (1.04–1.37)* CT 1.26 (1.1–1.44)* 1.25 (1.09–1.43)*
TT 1.11 (0.94–1.3) 1.09 (0.93–1.28) TT 1.12 (0.95–1.31) 1.1 (0.93–1.29) TT 1.12 (0.95–1.31) 1.08 (0.91–1.27)
High TG CC (reference) 1 1 CC (reference) 1 1 CC (reference) 1 1
CT 1.36 (1.19–1.55)* 1.38 (1.2–1.58)* CT 1.3 (1.14–1.48)* 1.33 (1.16–1.53)* CT 1.36 (1.2–1.56)* 1.39 (1.21–1.6)*
TT 1.78 (1.52–2.08)* 1.78 (1.5–2.1)* TT 1.8 (1.54–2.1)* 1.83 (1.55–2.16)* TT 1.84 (1.57–2.14)* 1.86 (1.57–2.19)*
High FBS CC (reference) 1 1 CC (reference) 1 1 CC (reference) 1 1
CT 0.85 (0.73–0.98)* 0.82 (0.71–0.96)* CT 0.84 (0.73–0.97)* 0.83 (0.71–0.97)* CT 0.83 (0.71–0.96)* 0.8 (0.68–0.94)*
TT 0.68 (0.57–0.82)* 0.64 (0.52–0.77)* TT 0.7 (0.58–0.84)* 0.65 (0.53–0.79)* TT 0.67 (0.56–0.8)* 0.63 (0.52–0.77)*
High blood pressure CC (reference) 1 1 CC (reference) 1 1 CC (reference) 1 1
CT 0.99 (0.87–1.14) 0.96 (0.83–1.13) CT 0.96 (0.83–1.1) 0.95 (0.81–1.1) CT 0.96 (0.84–1.11) 0.93 (0.8–1.09)
TT 1.20 (1.02–1.41)* 1.16 (0.97–1.4) TT 1.19 (1.01–1.4)* 1.16 (0.97–1.39) TT 1.2 (1.02–1.41)* 1.18 (0.98–1.42)
  1. High TG: TG ≥ 150 mg/dl and drug treatment; low HDL-C: HDL-C < 40 mg/dl in men and < 50 mg/dl in women and drug treatment; high blood pressure: SBP ≥ 130 mmHg and/or DBP ≥ 85 mmHg and drug treatment; high FBS: FBS ≥ 100 mg/dl and drug treatment; high waist circumference: waist circumference ≥ 90 cm for both genders
  2. CI confidence interval, OR odds ratio
  3. Model 1: unadjusted
  4. Model 2: adjusted for age, gender, and smoking
  5. *P < 0.0
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