Skip to main content

Table 2 Association of GCKR SNPs with MetS and qualitative MetS components in an additive genetic model

From: GCKR common functional polymorphisms are associated with metabolic syndrome and its components: a 10-year retrospective cohort study in Iranian adults

Categorical traits

rs780094

OR (CI) model 1

Adjusted OR (CI) model 2

rs780093

OR (CI) model 1

Adjusted OR (CI) model 2

rs1260326

OR (CI) model 1

Adjusted OR (CI) model 2

Metabolic syndrome

CC (reference)

1

1

CC (reference)

1

1

CC (reference)

1

1

CT

1.2 (1.06–1.36)*

1.22 (1.05–1.41)*

CT

1.11 (0.99–1.26)

1.14 (0.99–1.32)

CT

1.17 (1.04–1.33)*

1.19 (1.03–1.38)*

TT

1.3 (1.12–1.51)*

1.28 (1.08–1.53)*

TT

1.32 (1.14–1.53)*

1.34 (1.13–1.6)*

TT

1.29 (1.11–1.49)*

1.28 (1.08–1.53)*

High waist circumference

CC (reference)

1

1

CC (reference)

1

1

CC (reference)

1

1

CT

1.12 (0.99–1.27)

1.09 (0.95–1.25)

CT

1.08 (0.95–1.22)

1.08 (0.94–1.24)

CT

1.1 (0.97–1.25)

1.08 (0.94–1.24)

TT

1.18 (1.02–1.38)*

1.13 (0.96–1.34)

TT

1.2 (1.03–1.4)*

1.17 (0.99–1.39)

TT

1.2 (1.03–1.4)*

1.17 (0.99–1.38)

Low HDL-C

CC (reference)

1

1

CC (reference)

1

1

CC (reference)

1

1

CT

1.26 (1.1–1.44)*

1.25 (1.09–1.43)*

CT

1.21 (1.06–1.38)*

1.2 (1.04–1.37)*

CT

1.26 (1.1–1.44)*

1.25 (1.09–1.43)*

TT

1.11 (0.94–1.3)

1.09 (0.93–1.28)

TT

1.12 (0.95–1.31)

1.1 (0.93–1.29)

TT

1.12 (0.95–1.31)

1.08 (0.91–1.27)

High TG

CC (reference)

1

1

CC (reference)

1

1

CC (reference)

1

1

CT

1.36 (1.19–1.55)*

1.38 (1.2–1.58)*

CT

1.3 (1.14–1.48)*

1.33 (1.16–1.53)*

CT

1.36 (1.2–1.56)*

1.39 (1.21–1.6)*

TT

1.78 (1.52–2.08)*

1.78 (1.5–2.1)*

TT

1.8 (1.54–2.1)*

1.83 (1.55–2.16)*

TT

1.84 (1.57–2.14)*

1.86 (1.57–2.19)*

High FBS

CC (reference)

1

1

CC (reference)

1

1

CC (reference)

1

1

CT

0.85 (0.73–0.98)*

0.82 (0.71–0.96)*

CT

0.84 (0.73–0.97)*

0.83 (0.71–0.97)*

CT

0.83 (0.71–0.96)*

0.8 (0.68–0.94)*

TT

0.68 (0.57–0.82)*

0.64 (0.52–0.77)*

TT

0.7 (0.58–0.84)*

0.65 (0.53–0.79)*

TT

0.67 (0.56–0.8)*

0.63 (0.52–0.77)*

High blood pressure

CC (reference)

1

1

CC (reference)

1

1

CC (reference)

1

1

CT

0.99 (0.87–1.14)

0.96 (0.83–1.13)

CT

0.96 (0.83–1.1)

0.95 (0.81–1.1)

CT

0.96 (0.84–1.11)

0.93 (0.8–1.09)

TT

1.20 (1.02–1.41)*

1.16 (0.97–1.4)

TT

1.19 (1.01–1.4)*

1.16 (0.97–1.39)

TT

1.2 (1.02–1.41)*

1.18 (0.98–1.42)

  1. High TG: TG ≥ 150 mg/dl and drug treatment; low HDL-C: HDL-C < 40 mg/dl in men and < 50 mg/dl in women and drug treatment; high blood pressure: SBP ≥ 130 mmHg and/or DBP ≥ 85 mmHg and drug treatment; high FBS: FBS ≥ 100 mg/dl and drug treatment; high waist circumference: waist circumference ≥ 90 cm for both genders
  2. CI confidence interval, OR odds ratio
  3. Model 1: unadjusted
  4. Model 2: adjusted for age, gender, and smoking
  5. *P < 0.0