Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis

Spritzer, Poli Mara; Ramos, Ramon Bossardi; Marchesan, Lucas Bandeira; de Oliveira, Monica; Carmina, Enrico

doi:10.1186/s13098-021-00636-5

Diabetology & Metabolic Syndrome

Table 1 Characteristics of the studies included in the systematic review about Brazilian women with PCOS

From: Metabolic profile of women with PCOS in Brazil: a systematic review and meta-analysis

Name, Year	Region	PCOS criteria	Type of studies	N (PCOS/controls)	Age (PCOS/controls
BMI-unmatched studies
Avila et al. 2014 [30]	Southeast	Rotterdam	Cross-sectional	100/–	25.7 ± 4.9/–
Azevedo et al. 2011 [23]	Northeast	Rotterdam	Cross-sectional	113/242	26.2 ± 4.3/ 26.8 ± 5.0
Carvalho et al. 2017 [31]	Southeast	Rotterdam	Case–control	86/86	31.1 ± 4.92/29.0 ± 7.04
Cerqueira et al. 2010 [24]	Northeast	Rotterdam	Cross-sectional	56/54	26.2 ± 6.0/27.7 ± 6.1
Costa et al. 2012 [29]	Northeast	Rotterdam	Cross-sectional	113/–	27.2 ± 4.5/–
de Medeiros et al. 2014 [48]	Midwest	Rotterdam	Cross-sectional	288/–	26.9 ± 5.5/–
Gabrielli et al. 2012 [26]	Northeast	Rotterdam	Cross-sectional	73/725	28.4 ± 6.5/31.0 ± 7.3*
Graff et al. 2017 [44]	South	Rotterdam	Case–control	84/54	23.5 ± 6.3/26.2 ± 6.5
Kogure et al. 2012 [32]	Southeast	Rotterdam	Case–control	20/19	27.8 ± 5.0/27.9 ± 5.2
Maciel et al. 2014 [34]	Southeast	Rotterdam	Cross-sectional	97/–	24.9 ± 5.1/–
Melo et al. 2011^a [35]	Southeast	Rotterdam	Cross-sectional	132/146	26.6 ± 5.1/28.9 ± 0.5
Oliveira et al. 2013^b [36]	Southeast	Rotterdam	Case–control	42/18	27.4 ± 5.5/31.4 ± 6.1
Pedroso et al. 2012 [37]	Southeast	Rotterdam	Cross-sectional	105/–	29 ± 4.4/–
Pontes et al. 2012 [38]	Southeast	Rotterdam	Cross-sectional	189/–	24.9 ± 5.2/–
Radavelli-Bagatini et al. 2013 [45]	South	Rotterdam	Case–control	80/1500	21.3 ± 0.6/22.7 ± 0.4
Ramos et al. 2015 [46]	South	Rotterdam	Case–control	199/99	22 ± 6/25 ± 7
Santana et al. 2004^c [40]	Southeast	NIH	Cohort	21/–	27.2/–
Soares et al. 2016 [27]	Northeast	Rotterdam	Cross-sectional	22/–	26 ± 6.0/–
Tavares et al. 2019 [28]	Northeast	Rotterdam	Cross-sectional	111/–	18–39
Wanderley et al., 2018 [49]	Midwest	Rotterdam	Cross-sectional	83/–	28.79 ± 5.85/–
Wiltgen et al. 2010^d [43]	South	Rotterdam	Case–control	195/25	22.3 ± 6.7/29.7 ± 4.29*
Xavier et al. 2018 [42]	Southeast	Rotterdam	Case–control	97/99	30.5 ± 5.1/29.8 ± 7.1
BMI-matched studies
Costa et al., 2008 [25]	Northeast	Rotterdam	Cross-sectional	57/37	25.5 ± 5.3/26.6 ± 5.4
Lauria et al. 2013 [33]	Southeast	Rotterdam	Case–control	40/36	29 (25–34)/30(15–43)
Rocha et al. 2011 [39]	Southeast	Rotterdam	Case–control	142/31	25.1 ± 5.4/27.5 ± 4
Simões et al. 2017 [41]	Southeast	Rotterdam	Case–control	10/10	29.6 ± 1.2/28.6 ± 2.0
Wiltgen et al. 2009 [47]	South	Rotterdam	Case–control	51/44	20.6 ± 5.1/28.9 ± 5.6*

^aData are from A phenotype PCOS vs controls
^bWomen included in the control group had similar complaints as the ones from the PCOS group, but did not fulfill the diagnostic criteria
^cData are from baseline
^dData are from A plus B phenotypes PCOS vs controls
*p < 0.05 between groups

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