Table 1 Characteristics of the studies included in this meta-analysis
From: Increased levels of YKL-40 in patients with diabetes mellitus: a systematic review and meta-analysis
Study | Region | Year | Type of DM | No. of DM patients | No. of healthy controls | Mean age of DM patients | Mean age of healthy controls | Diagnosis criteria | Method |
|---|---|---|---|---|---|---|---|---|---|
Jian Li et al. [15] | China | 2015 | GDM | 35 | 43 | 29.3 ± 3.1 | 30.6 ± 3.8 | ADA 2012 | ELISA (Quidel, USA) |
Rathcke et al. [16] | Denmark | 2005 | T2DM | 87 | 158 | 54.2 (40–70)a | NA | National Diabetes Data Group 1979 | ELISA (Quidel, USA) |
Thomsen et al. [17] | Denmark | 2010 | T2DM | 45 | 20 | 54 (41–73)b | 50 (34–66)b | NA | ELISA (Quidel, USA) |
Schaller et al. [18] | Austria | 2010 | GDM | 28 | 30 | 33 ± 6 | 33 ± 4 | ADA criteria for GDM 2004 | ELISA (Quidel, USA) |
Sakamoto et al. [19] | Japan | 2013 | T1DM | 131 | 97 | 24.7 ± 5.9 | 25.5 ± 2.7 | NA | ELISA (Quidel, USA) |
Rinnov et al. [20] | Denmark | 2015 | GDM | 10 | 8 | 31.1 ± 5.6 | 28.1 ± 1.8 | OGTT 2 h GLU ≥ 9.0 mM | ELISA (Quidel, USA) |
Abd El Dayem et al. [21] | Egypt | 2015 | T1DM | 62 | 30 | 16.32 ± 1.52 | 16.13 ± 2.63 | NA | ELISA (Quidel, USA) |
Shiasi et al. [22] | Iran | 2017 | T1DM | 49 | 43 | 12.20 ± 3.86 | 10.95 ± 3.83 | ADA | ELISA (Quidel, USA) |
Rekha Kumari et al. [23] | India | 2015 | T2DM | 30 | 30 | 44.4 ± 2.7 | 45.95 ± 3.4 | NA | ELISA |
Song Wei et al. [24] | China | 2015 | T2DM | 210 | 210 | 58.29 ± 5.94 | 59.98 ± 7.53 | NA | ELISA (Quidel, USA) |
Ye Kejun et al. [25] | China | 2016 | GDM | 50 | 50 | 27.2 ± 3.4 | 28.6 ± 3.8 | ADA 2005 | ELISA |
Chen Qingfu et al. [26] | China | 2014 | T2DM | 48 | 45 | NA | 48.1 ± 13.7 | WHO 1999 | ELISA (Quidel, USA) |
Li Peng et al. [27] | China | 2011 | T2DM | 41 | 40 | 54.61 ± 12.37 | 42.8 ± 13.52 | NA | ELISA (Becton,Dickinson and Company, USA) |
Lin Lijun et al. [28] | China | 2019 | T2DM | 42 | 40 | NA | NA | NA | ELISA |
Xun Shengli et al. [29] | China | 2017 | GDM | 60 | 20 | 27.85 ± 4.48 | 26.82 ± 3.10 | Obstetrics and gynecology [M] | ELISA |
Yu Yeye et al. [30] | China | 2018 | T2DM | 60 | 60 | 46.48 ± 11.54 | 47.83 ± 9.68 | ADA 2007 | ELISA |
Ren Lijue et al. [31] | China | 2019 | T2DM | 30 | 30 | 57.20 ± 10.30 | 54.5 ± 10.44 | WHO 1999 | ELISA |
Rathcke et al. [32] | Denmark | 2009 | T1DM | 58A/46B/45C | 55 | 55.6 ± 10.8A/54 ± 11.1B/49 ± 9.6C | 50.5 ± 10.9 | NA | ELISA (Quidel, USA) |
Røndbjerg et al. [33] | Denmark | 2011 | T2DM | 49A/35B/21C | 20 | 61.3 ± 12.0A/60.1 ± 11.7B/64 ± 13.1C | 57.1 ± 7.2 | NA | ELISA (Quidel, USA) |
Lee et al. [34] | South Korea | 2012 | T2DM | 25A/25B/25C | 22 | 55.6 ± 11.1A/57.0 ± 11.6B/56.0 ± 9.8C | 52.4 ± 5.8 | NA | ELISA |
Han et al. [13] | China | 2015 | T2DM | 260A/246B/232C | 210 | 52.83 ± 4.30A/53.93 ± 4.56B/ 53.93 ± 4.22C | 53.40 ± 4.28 | ADA 2007 | ELISA (Bio-Technology Co. Ltd., USA) |
Umapathy et al. [35] | India | 2018 | T2DM | 81A/73B/69C | 83 | 54.07 ± 11.09A/55.1 ± 10.9B/57.39 ± 5.39C | 52.59 ± 12.9 | NA | a multiplex bead-based assay system (Bio-Rad, Hercules, California, USA) |
Zhu Huijing et al. [36] | China | 2015 | T2DM | 23A/24B/23C | 20 | 63.00 ± 13.76A/65.33 ± 9.13B/66.35 ± 7.84C | 62.0 ± 11.16 | ADA 2007 | ELISA |
Wang Huan et al. [37] | China | 2015 | T2DM | 21B/39C | 30 | NA | 68 ± 8 | NA | ELISA (Quidel, USA) |
Yu Zhixuan et al. [38] | China | 2017 | T2DM | 30A/30B | 30 | NA | 55.45 ± 7.36 | NA | ELISA |