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Table 2 Correlations between BMI changes and delta of gene expression in adipose tissue at 3 and 6 months after RYGB

From: Bariatric surgery can acutely modulate ER-stress and inflammation on subcutaneous adipose tissue in non-diabetic patients with obesity

  Correlation statistics   Correlation statistics
Pearson’s r p value Pearson’s r p value
3 months    6 months   
 IL6 0.362 0.548  IL6 -0.305 0.5046
 TNFα 0.344 0.570  TNFα -0.555 0.1954
 MCP1 0.497 0.394  MCP1 0.183 0.6942
 ADIPOQ -0.066 0.915 ADIPOQ 0.950 0.0010
PGC1α 0.961 0.009  PGC1α 0.386 0.3915
 PPARγ 0.384 0.523  PPARγ 0.591 0.1623
 EIF2AK3 0.511 0.379  EIF2AK3 0.165 0.7233
 ATF4 0.648 0.237 ATF4 -0.373 0.4097
 ATF6 0.410 0.492 ATF6 0.677 0.0945
 CHOP 0.254 0.680 CHOP -0.286 0.5332
GRP78 0.261 0.671 GRP78 0.46 0.2987
GADD34 -0.554 0.332 GADD34 -0.05 0.9141
XBP1 -0.609 0.275 XBP1 0.232 0.6164
CALR 0.004 0.994 CALR 0.416 0.3523
CANX 0.490 0.401 CANX 0.743 0.0554
CCT4 0.637 0.247 CCT4 0.272 0.5539
SIRT1 0.958 0.010 SIRT1 0.844 0.0169
SIRT3 0.407 0.496 SIRT3 0.489 0.2646
AMPK 0.947 0.015 AMPK 0.692 0.0846
GCN2 -0.511 0.379 GCN2 0.278 0.5459
NRF2 0.127 0.839 NRF2 -0.014 0.9757
SOD1 -0.342 0.573 SOD1 -0.527 0.2232
SOD2 -0.710 0.178 SOD2 -0.112 0.8102
SOD3 -0.466 0.428 SOD3 0.105 0.8227
  1. IL6: Interleukin 6; TNF-ɑ: Tumor necrosis factor-α; MCP-1: Monocyte chemoattractant protein-1; PGC1ɑ: Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PPARϒ: Peroxisome proliferator activated receptor gamma; EIF2AK3: Eukaryotic translation initiation factor 2 alpha kinase 3; ATF4: Activating Transcription Factor 4; ATF6: Activating Transcription Factor 6; CHOP: C/EBP homologous protein; GRP78: Heat shock protein family A (Hsp70) member 5; GADD34: growth arrest and DNA damage-inducible protein; XBP1: X-box binding protein 1; CARL: Calreticulin; CANX: Calnexin; CCT4: Chaperonin Containing TCP1 Subunit 4; SIRT1: Sirtuin 1; SIRT3: Sirtuin 3; AMPK: AMP-activated protein kinase; GCN2: General control nonderepressible 2; NRF2: Nuclear factor erythroid 2-related factor 2; SOD1: Superoxide dismutase 1; SOD2: Superoxide dismutase 2, SOD3: Superoxide dismutase 3
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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