Table 1 MicroRNA (miR) Deregulation in Obesity and Breast Cancer

21

TGF-βR2 inhibition

PTEN inhibition, reduced AP-1

PTEN inhibition,

PI3K/Akt activation

[49,50,51]

24-3p

Inhibit SR-B1 that regulate cholesterol uptake, increase HMGCR, DHCR24 and SREBP2

Inhibit p27Kip1, inhibit Bim, cell cycle proliferation

[52,53,54]

155

Upregulated in inflammation targets PPAR-γ

Downregulate SOC-1, upregulate MMP6

[55, 56]

210

Inhibit Wnt signaling, increase adipogenesis

E-cadherin, HIF1-α, metastasis, proliferation

[57,58,59]

221/222

Erα, GLUT4, reduced insulin stimulation of glucose uptake

Inhibit PTEN and p27(Kip), activate Akt, ER-alpha, inhibit IncRNA GAS5 down regulate MYC, increase proliferation, cell cycle, survival

[60,61,62,63,64,65,66]

3184-3p

FOXP4–NOTCH induced EMT pathway proliferation of MABC

cells

[67]

let-7

Inhibit HMGA2, inhibit preadipocyte proliferation

Inhibit HMGA2, MYC, JAK-STAT-3, Caspase-3, RAS, CCND2, Erα decrease invasion tumor suppressor function

[78,79,80]

26b

Inhibit PTEN/PI3K/AKT pathway to modulate insulin sensitivity

Serpin B2, anti-metastasis and anti-invasion

[68,69,70]

27b

Control lipid metabolisms inhibit PPAR-γ

FOXO1, ST14

BAK

SPRY2

TMEM170B

CBLB/GRB2

apoptosis, cell-cycle

checkpoint

[81,82,83,84,85]

30a

Suppression of STAT1 to limit Interferon γ-signaling

Cyclin E2; anti proliferative G1, cell cycle arrest

[71,72,73]

181c-3p

PPARα; reduced inhibition of PPARα, BC proliferation

[67]

143-3p

PPAR-γ, AP2, leptin pathway, ERK5

DNMT3A, PTEN hypermethylation, increase TNFRS F10c methylation, KRAS, AKT1, BCL2

[44]

148a-3p

inhibit DNMT1 which is correlated with obesity

WNT-1, β-catenin, MMP-7, TCF-4, BCl-2, caspases, anti metastasis, anti invasion by regulating Wnt/β-catenin signaling pathway

[74, 75]

302b

Maintain SOX2 and c-Myc by targeting repressor of c-Myc

Target RUNX2, that activate PI3K/AKT signaling and regulate proliferation

[76, 77]

34a

Inhibit macrophage M2 induced adipose inflammation

Inhibit BCL2, CCND1, MYC, E2F3, CDK6, SIRT1

anti-apoptosis

[86,87,88,89,90,91,92]