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Table 5 Odds of the dementia in Alzheimer’s type or VD according to vascular risk factors

From: Associations between metabolic syndrome and type of dementia: analysis based on the National Health Insurance Service database of Gangwon province in South Korea

  Alzheimer’s disease Vascular dementia
Model 1 Model 2 Model 3 Model 1 Model 2 Model 3
OR (95% CI) p value OR (95% CI) p value OR (95% CI) p value OR (95% CI) p value OR (95% CI) p value OR (95% CI) p value
BMI 1.059 (1.042, 1.075) < 0.0001 0.958 (0.941, 0.975) < 0.0001 0.951 (0.927, 0.975) < 0.0001 1.008 (0.984, 1.032) 0.528 0.998 (0.973, 1.023) 0.857 0.988 (0.952, 1.024) 0.504
Systolic BP 1.014 (1.011, 1.017) < 0.0001 1.000 (0.995, 1.004) 0.882 0.999 (0.992, 1.005) 0.651 1.000 (0.996, 1.005) 0.855 0.994 (0.988, 1.000) 0.063 0.999 (0.990, 1.008) 0.788
Diastolic BP 1.014 (1.009, 1.018) < 0.0001 0.996 (0.990, 1.002) 0.214 1.001 (0.991, 1.010) 0.916 1.007 (0.999, 1.014) 0.071 1.002 (1.002, 1.022) 0.019 1.004 (0.990, 1.019) 0.575
Fasting glucose 1.009 (1.008, 1.011) < 0.0001 1.004 (1.002, 1.005) < 0.0001 1.003 (1.001, 1.005) 0.003 1.005 (1.003, 1.007) < 0.0001 1.002 (1.002, 1.007)  < 0.0001 1.004 (1.001, 1.008) 0.012
Total cholesterol 1.001 (1.000, 1.002) 0.003 1.001 (1.000, 1.002) 0.211 1.000 (0.998, 1.002) 0.793 1.000 (0.999, 1.002) 0.662 0.999 (0.999, 1.002) 0.793 1.000 (0.997, 1.003) 0.998
Smoking 1.007 (0.994, 1.021) 0.282    1.020 (1.003, 1.039) 0.024 0.928 (0.892, 0.966) < 0.0001    0.988 (0.962, 1.014) 0.352
Alcohol 0.995 (0.969, 1.021) 0.694    0.979 (0.940, 1.019) 0.302 0.972 (0.936, 1.011) 0.155    1.014 (0.972, 1.056) 0.525
Physical inactivity 0.935 (0.945, 1.163) 0.415    0.997 (0.838, 1.188) 0.977 0.974 (0.836, 1.136) 0.741    0.898 (0.700, 1.153) 0.399
Previous stroke 2.248 (1.757, 2.874) < 0.0001    1.827 (1.263, 2.644) 0.001 2.461 (1.753, 3.445)  < 0.0001    2.775 (1.747, 4.406) < 0.0001
Previous cardiac disease 1.213 (1.004, 1.467) 0.046    1.088 (0.836, 1.416) 0.532 0.825 (0.598, 1.139) 0.242    0.702 (0.434, 1.136) 0.150
  1. Model 1: separate models associated each exposure variable with AD or VD with adjustment for age and sex
  2. Model 2: single model including age, sex, metabolic syndrome, BMI, systolic BP, diastolic BP, fasting glucose, total cholesterol
  3. Model 3: single model including age, sex, metabolic syndrome, BMI, systolic BP, diastolic BP, fasting glucose, total cholesterol, smoking, alcohol, physical inactivity, previous stroke and previous cardiac disease
  4. OR odds ratio, CI confidence interval, BMI body mass index, BP blood pressure