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Fig. 4 | Diabetology & Metabolic Syndrome

Fig. 4

From: Toxic AGEs (TAGE) theory: a new concept for preventing the development of diseases related to lifestyle

Fig. 4

Conclusions/perspectives. a TAGE are a novel target for preventing the onset and/or progression of LSRD. b The onset and progression of LSRD are associated with habitual excessive intake of sugars/dietary AGEs. c Suppressing the generation/accumulation of TAGE may prevent the onset and/or progression of LSRD. The following strategies are recommended: (i) avoid habitual excessive intake of unhealthy beverages and/or food; (ii) increase the habitual intake of Japanese foods that suppress the generation/accumulation of TAGE; and (iii) adopt a vegetables-first and/or carbohydrates-last eating order to reduce rapid increases in blood sugar levels. The maintenance of dietary habits, as described above, represents a novel strategy for achieving a healthy and long life by suppressing the generation/accumulation of TAGE in the body, which contributes to the prevention of LSRD. AD: Alzheimer’s diseases; CKD: chronic kidney disease; CVD: cardiovascular disease; DM: diabetes mellitus; HFCS: high-fructose corn syrup; LSRD: lifestyle-related diseases; NASH: nonalcoholic steatohepatitis; RAGE: receptor for AGEs; ROS: reactive oxygen species; SSB: sugar-sweetened beverages; TAGE: toxic AGEs

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