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Table 3 Hazard ratio and 95% confidence interval for incidence of type 2 diabetes in early adulthood based on metabolic syndrome and its components, 1999–2015 (n = 2798)

From: Adolescent metabolic syndrome and its components associations with incidence of type 2 diabetes in early adulthood: Tehran lipid and glucose study

  n Incidence rate (per 10,000 person-years) Model 1 Model 2
Components
 High WC 462 27.95 2.63 (1.39–4.97)* 1.92 (0.93–3.97)
 High BP 456 18.74 1.58 (0.77–3.22) 1.37 (0.66–2.81)
 Low HDL-C 1295 15.68 1.20 (0.66–2.18) 1.11 (0.61–2.01)
 High TGs 1030 18.70 1.82 (1.00–3.34)* 1.68 (0.92–3.09)
 High FPG 199 17.19 1.51 (0.53–4.26) 1.49 (0.53–4.22)
Dual combinations
 High TGs and high WC 285 34.79 3.56 (1.78–7.10)* 2.70 (1.27–5.77)*
 High FPG and high WC 39 21.53 1.70 (0.23–12.42) 1.37 (0.19–10.09)
 Low HDL-C and high WC 269 27.12 2.42 (1.12–5.23)* 1.66 (0.71–3.85)
 High BP and high WC 126 43.37 3.84 (1.62–9.13)* 2.52 (1.00–6.33)*
 High TGs and high FPG 87 19.58 1.58 (0.38–6.61) 1.50 (0.36–6.28)
 High TGs and low HDL-C 621 21.14 1.86 (0.99–3.49)* 1.68 (0.89–3.17)
 High TGs and high BP 215 31.38 2.83 (1.29–6.16)* 2.27 (1.02–5.05)*
 High FPG and low HDL-C 92 27.54 2.41 (0.74–7.83) 2.08 (0.64–6.80)
 High FPG and high BP 36 42.33 3.79 (0.91–15.76) 3.35 (0.80-14.08)
 Low HDL-C and high BP 190 31.47 2.67 (1.18–6.01)* 2.15 (0.94–4.90)
 Metabolic syndrome 338 33.78 3.55 (1.84–6.87)* 2.82 (1.41–5.64)*
  1. Incidence rate, number of incident type 2 diabetes cases divided by person-year follow up
  2. Model 1 is adjusted for age and sex; model 2 is further adjusted for adulthood body mass index and family history of diabetes
  3. WC waist circumference, SBP systolic blood pressure, DBP diastolic blood pressure, HDL-C high-density lipoprotein cholesterol, TGs triglycerides, FPG fasting plasma glucose
  4. *P-value ≤ 0.05