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Table 1 Demographic, clinical and biochemical characteristics of type 2 diabetes individuals sorted according to the status of cardiovascular autonomic neuropathy (CAN)

From: Increased leukotriene B4 plasma concentration in type 2 diabetes individuals with cardiovascular autonomic neuropathy

Demographic. clinical and biochemical characteristics Without definitive CAN With definitive CAN P value
n 85 44  
Age (years) 63 (60–67) 62 (58–67) 0.43
Sex (% female) 60 65 0.56
Ethnicity (Caucasoid/Negroid/Asiatic) (%) 68/28/4 73/27/0 0.60
Body mass index (kg m2) 29.6 (26.4–35.7) 28.8 (25.9–33.3) 0.35
Waist circumference (cm) 103 (97–115) 102 (96–110) 0.91
Arterial hypertension (%) 74 84 0.19
Smoking (%) 10.6 13.6 0.61
Total cholesterol (mg dL−1) 193 (165–234) 203 (167–233) 0.60
HDL (mg dL−1) 47 (38–56) 44 (35–52) 0.16
LDL (mg dL−1) 118 (94–150) 113 (89–147) 0.52
Triglycerides (mg dL−1) 144 (111–218) 184 (132–212) 0.05
Lipid accumulation product index 71.1 (54.4–110.4) 80.5 (60.1–151.4) 0.06
Diabetes status
 Diabetes duration (years) 8 (4–13) 9 (4–20) 0.34
 HbA1C (%) 7.3 (6.2–9.2) 7.5 (6.4–9.1) 0.94
 (mmol.mol−1) 56 (44–77) 58 (46–76)  
 eGFR < 60 mL.min−1.1.73m2 (%) 16 11 0.57
 Distal symmetric polyneuropathy (%) 11.7 13.6 0.75
Inflammatory mediators
 Leukotriene B4 (pg mL−1) 63.1 ± 16.4 71.5 ± 15.7 0.006
 Tumor necrosis factor (pg mL−1) 1.9 ± 7.9 7.4 ± 36.0 0.001
 Interleukin 1B (pg mL−1) 23.6 ± 106.3 9.2 ± 18.1 0.32
 Interleukin 10 (pg mL−1) 5.5 ± 13.5 3.8 ± 14.2 0.002
  1. Data are expressed as median (interquartile range), except for the inflammatory mediators, which are expressed as mean ± SD. eGFR: estimated glomerular filtration rate
  2. HDL: High-density lipoprotein; LDL: Low-density lipoprotein. Arterial hypertension defined as systolic/diastolic blood pressure ≥ 140/90 mmHg or use of anti-hypertensive drugs not for renal protection purposes; Hypercholesterolemia defined as an LDL > 100 mg.dL−1 or use of statin. Differences between groups were assessed by the Wilcoxon and by the Pearson’s χ2tests. Significantly different variables are shown in italic