Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects

Table 5 Multivariate linear regression analyses for serum adipsin levels in T2DM patients

	Model 1			Model 2
	n	β	P	n	β	P
Serum soluble EGFR (ng/mL)	106	0.117	0.273
BMI	106	0.541	< 0.001	106	0.470	< 0.001
Waist circumference (cm)	71	0.523	< 0.001	71	0.451	< 0.001
Systolic blood pressure (mmHg)	102	0.045	0.653
Diastolic blood pressure (mmHg)	102	0.060	0.565
Fasting blood glucose (mg/dL)	106	− 0.106	0.280
Fasting serum insulin (μIU/mL)	83	0.381	< 0.001	83	0.345	0.001
C-peptide (ng/mL)	100	0.187	0.076
HOMA-IR	83	0.312	0.006	83	0.281	0.009
CPR-index	100	0.224	0.031	100	0.199	0.045
HbA1c (%, mmol/mol)	106	0.044	0.659
Total cholesterol (mg/dL)	102	0.001	0.992
LDL-cholesterol (mg/dL)	105	− 0.133	0.178
HDL-cholesterol (mg/dL)	106	− 0.035	0.736
Triglycerides (mg/dL)	106	− 0.019	0.859
AST (IU/L)	106	0.112	0.261
ALT (IU/L)	106	0.106	0.308
γGTP (IU/L)	105	0.133	0.188
FIB4-index	95	0.214	0.045	95	0.277	0.007
eGFR (mL/min/1.73 m²)	106	− 0.380	< 0.001	–	–	–

Model 1: Adjusted for age and sex
Model 2: Adjusted for age, sex, and eGFR levels
BMI, Body mass index; EGFR, Epidermal growth factor receptor; eGFR, Estimated glomerular filtration rate; T2DM, Type 2 diabetes

ISSN: 1758-5996