Soluble EGFR, a hepatokine, and adipsin, an adipokine, are biomarkers correlated with distinct aspects of insulin resistance in type 2 diabetes subjects

Table 4 Univariate linear regression analyses for serum adipsin levels in T2DM patients and NGT subjects

	NGT			T2DM
	n	β	P	n	β	P
Serum soluble EGFR (ng/mL)	47	0.035	0.815	106	0.095	0.332
Age (years)	47	0.021	0.887	106	− 0.039	0.693
Sex	47	− 0.147	0.323	106	− 0.162	0.098
BMI	47	0.520	< 0.001	106	0.420	< 0.001
Waist circumference (cm)	25	0.620	< 0.001	71	0.430	< 0.001
Systolic blood pressure (mmHg)	42	− 0.023	0.885	102	0.066	0.508
Diastolic blood pressure (mmHg)	42	0.080	0.613	102	0.098	0.328
Fasting blood glucose (mg/dL)	46	0.057	0.709	106	− 0.114	0.244
Fasting serum insulin (μIU/mL)	41	0.195	0.223	83	0.365	< 0.001
C-peptide (ng/mL)	29	0.304	0.109	100	0.157	0.119
HOMA-IR	41	0.194	0.225	83	0.300	0.006
CPR-index	29	0.324	0.086	100	0.184	0.067
HbA1c (%, mmol/mol)	45	− 0.012	0.940	106	0.058	0.553
Total cholesterol (mg/dL)	41	− 0.123	0.445	102	− 0.002	0.983
LDL-cholesterol (mg/dL)	45	− 0.011	0.943	105	0.141	0.150
HDL-cholesterol (mg/dL)	45	− 0.315	0.035	106	− 0.071	0.468
Triglycerides (mg/dL)	45	0.088	0.565	106	0.009	0.930
AST (IU/L)	45	0.157	0.303	106	0.133	0.174
ALT (IU/L)	45	0.187	0.219	106	0.133	0.173
γGTP (IU/L)	44	0.079	0.611	105	0.158	0.107
FIB4-index	27	− 0.018	0.931	95	0.226	0.028
eGFR (mL/min/1.73 m²)	47	− 0.365	0.012	106	− 0.339	< 0.001

BMI, Body mass index; EGFR, Epidermal growth factor receptor; eGFR, Estimated glomerular filtration rate; NGT, Normal glucose tolerance; T2DM, Type 2 diabetes

ISSN: 1758-5996