Table 1 Serum soluble EGFR and adipsin levels and metabolic characteristics of T2DM patients and NGT subjects

Serum soluble EGFR (ng/mL)

47

62.3 ± 1.2

106

64.7 ± 0.9

0.11

Serum adipsin (μg/mL)

47

5.9 ± 0.3

106

5.8 [4.7–7.1]

0.55

Age (years)

47

54 [44–65]

106

56 [49–65]

0.06

Sex (No. men/women)

13/34

–

66/40

–

< 0.01

BMI

47

22.9 [20.6–29.4]

106

27.1 [23.9–30.9]

0.21

Waist circumference (cm)

25

90.0 [82.8–105.0]

71

96.0 [88.0–105.0]

0.33

Systolic blood pressure (mmHg)

42

126.5 [114.5–145.3]

102

134.4 ± 1.9

0.26

Diastolic blood pressure (mmHg)

42

82.2 ± 2.2

102

84.2 ± 1.3

0.4

Fasting blood glucose (mg/dL)

46

100.2 ± 1.3

106

161.0 [134.8–184.0]

< 0.01

Fasting serum insulin (μIU/mL)

41

8.2 [4.9–10]

83

9.6 [6.0–15.5]

0.16

C-peptide (ng/mL)

29

2.2 [1.4–3.2]

100

2.4 [1.6–3.2]

0.84

HOMA-IR

41

2.2 [1.1–2.7]

83

4.0 [2.4–6.4]

< 0.01

CPR-index

29

2.1 [1.5–2.9]

100

1.4 [0.9–2.1]

< 0.01

HbA1c (%)

45

5.7 ± 0.1

106

9.3 [7.9–10.2]

< 0.01

HbA1c (mmol/mol)

45

39 ± 0.5

106

78 [63–88]

< 0.01

Total cholesterol (mg/dL)

41

200 ± 5.9

102

187.0 [165.8–211.0]

0.24

LDL-cholesterol (mg/dL)

45

122.6 ± 4.6

105

110.0 [89.5–126.5]

0.03

HDL-cholesterol (mg/dL)

45

61.2 ± 2.6

106

42.0 [37.0–54.0]

< 0.01

Triglycerides (mg/dL)

45

100.0 [78.0–128.5]

106

141.5 [96–213.5]

< 0.01

AST (IU/L)

45

20.0 [15.5–22.5]

106

24.0 [18.0–38.0]

< 0.01

ALT (IU/L)

45

17.0 [11.0–25.5]

106

28.5 [19.0–50.0]

< 0.01

γGTP (IU/L)

44

21.5 [14.3–31.3]

105

37.0 [23.0–67.5]

0.04

FIB4-index

27

1.0 ± 0.1

95

1.6 ± 0.2

< 0.01

eGFR (mL/min/1.73 m²)

47

81.3 ± 2.5

106

83.2 ± 2.0

0.58