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Fig. 1 | Diabetology & Metabolic Syndrome

Fig. 1

From: LncRNA KCNQ1OT1 affects cell proliferation, apoptosis and fibrosis through regulating miR-18b-5p/SORBS2 axis and NF-ĸB pathway in diabetic nephropathy

Fig. 1

KCNQ1OT1 and SORBS2 were upregulated in DN patients and high glucose-induced HGMCs and HRGECs. a the expression of KCNQ1OT1 was detected in the serum of DN patients (n = 30) by qRT-PCR. b, c The mRNA and protein levels of SORBS2 were detected in the serum of DN patients (n = 30) by qRT-PCR and western blot. d the correlation of the KCNQ1OT1 level and SORBS2 mRNA level in the serum of DN patients was analyzed. e cell viability of HGMCs treated with 0, 10, 20, or 30 mM glucose was measured by CCK-8. f the expression of KCNQ1OT1 was detected in high glucose-induced and normal HGMCs and HRGECs by qRT-PCR. g and h the mRNA and protein levels were detected in high glucose-induced and normal HGMCs and HRGECs by qRT-PCR and western blot. N = 3, *P < 0.05

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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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