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Table 2 Merged quantitative analyses results of the current study

From: Whether the risk of gestational diabetes mellitus is affected by TNF-α, IL-6, IL-10 or ADIPOQ polymorphisms: a meta-analysis

Variables

Sample size

Dominant comparison (MM vs. Mm + mm)

Recessive comparison (mm vs. MM + Mm)

Overdominant comparison (Mm vs. MM + mm)

Allele comparison (M vs. m)

p value

OR (95% CI)

p value

OR (95% CI)

p value

OR (95% CI)

p value

OR (95% CI)

TNF-α − 238 G/A rs361525

 Overall (Mixed population)

171/164

0.53

0.81 (0.42–1.57)

0.55

2.64 (0.11–66.55)

0.63

1.18 (0.60–2.29)

0.45

0.79 (0.42–1.48)

TNF-α − 308 G/A rs1800629

 Overall (Mixed population)

639/683

0.15

0.81 (0.60–1.08)

0.16

1.60 (0.84–3.04)

0.42

1.14 (0.83–1.55)

0.09

0.80 (0.62–1.04)

 Asian

509/471

0.29

0.83 (0.58–1.17)

0.17

1.66 (0.81–3.41)

0.97

1.01 (0.54–1.89)

0.18

0.81 (0.60–1.10)

IL6 − 174 G/C rs1800795

 Overall (Mixed population)

253/275

0.32

0.78 (0.48–1.27)

0.18

1.91 (0.74–4.96)

0.75

1.09 (0.65–1.80)

0.15

0.74 (0.49–1.11)

 Asian

174/110

0.28

0.55 (0.19–1.62)

0.78

1.59 (0.06–39.61)

0.35

1.68 (0.57–4.97)

0.23

0.52 (0.18–1.50)

IL-10 − 819C/T rs1800871

 Overall (Asian)

182/202

0.64

0.91 (0.60–1.37)

0.33

0.74 (0.40–1.35)

0.26

1.26 (0.84–1.89)

0.88

1.02 (0.76–1.38)

IL-10 − 592C/A rs1800872

 Overall (Mixed population)

386/409

0.20

1.20 (0.91–1.60)

0.34

0.79 (0.50–1.27)

0.49

0.90 (0.68–1.20)

0.23

1.14 (0.92–1.42)

 Asian

182/202

0.47

1.16 (0.77–1.76)

0.92

1.03 (0.56–1.91)

0.44

0.85 (0.57–1.28)

0.63

1.07 (0.80–1.45)

IL-10 − 1082A/G rs1800896

 Overall (Mixed population)

262/367

0.64

1.09 (0.75–1.58)

0.75

1.13 (0.53–2.39)

0.52

0.88 (0.60–1.29)

0.79

1.04 (0.77–1.42)

 Asian

182/202

0.80

1.07 (0.64–1.78)

0.82

1.17 (0.30–4.47)

0.73

0.91 (0.53–1.55)

0.89

1.03 (0.66–1.63)

ADIPOQ + 45T/G rs2241766

 Overall (Mixed population)

1461/1592

< 0.001

0.70 (0.60–0.81)

< 0.001

1.95 (1.48–2.56)

0.03

1.18 (1.02–1.37)

 < 0.001

0.71 (0.64–0.80)

 Asian

1317/1353

< 0.001

0.70 (0.60–0.82)

< 0.001

1.94 (1.47–2.57)

0.08

1.15 (0.98–1.34)

 < 0.001

0.72 (0.64–0.81)

ADIPOQ + 276G/T rs1501299

 Overall (Asian)

902/993

0.50

0.94 (0.78–1.13)

0.41

0.87 (0.63–1.21) 0.87 (0.63–1.21)

0.49

1.07 (0.89–1.28)

0.61

0.96 (0.84–1.11)

  1. All investigated polymorphisms contain a major allele (M) and a minor allele (m), The dominant comparison was defined as MM vs. Mm + mm, the recessive comparison was defined as mm vs. MM + Mm, the over-dominant comparison was defined as Mm vs. MM + mm, and the allele comparison was defined as M vs. m (MM stands for homozygote of the major allele, Mm stands for heterozygote of the major allele and the minor allele, and mm stands for homozygote of the minor allele)
  2. The values in italics represent there is statistically significant differences between cases and controls
  3. OR, odds ratio; CI, confidence interval; NA, not available; UC, ulcerative colitis; CD, Crohn’s disease
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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