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Table 5 Pre-treatment vs post-treatment comparison of clinical and biochemical parameters in T2DM patients with vitamin D3 plus K2 supplementation

From: Effect of supplementation with vitamins D3 and K2 on undercarboxylated osteocalcin and insulin serum levels in patients with type 2 diabetes mellitus: a randomized, double-blind, clinical trial

Variable

Initial n = 12

Final n = 12

p value

Glucose (mg/dL)

138 ± 40

123 ± 39

0.002

HOMA-IR

3.9 ± 2.5

3.5 ± 2.1

0.388

%FPβC

622 ± 444

281 ± 187

0.004

SBP (mmHg)

136 ± 23

126 ± 22

0.209

DBP (mmHg)

80 ± 8

76 ± 10

0.286

Cholesterol (mg/dL)

204 ± 25

194 ± 36

0.530

Triglycerides (mg/dL)

179 ± 106

154 ± 44

0.937

VLDL (mg/dL)

35 ± 21

30 ± 8

0.937

uOC (ng/dL)

2.0 ± 1.0

2.1 ± 1.1

1.000

cOC (ng/dL

0.441 ± 0.304

0.611 ± 0.278

0.065

uOC/cOC index

6.4 ± 4.2

4.3 ± 2.9

0.023

Insulin (ng/dL)

114 ± 76

113 ± 55

0.638

Muscle (%)

50 ± 10

50 ± 11

0.182

Fat (%)

34 ± 14

31 ± 11

0.433

BMI (kg/m2)

27 ± 4

28 ± 4

0.050

Weight (kg)

77 ± 15

78 ± 15

0.055

  1. HOMA-IR homeostatic model assessment-insulin resistance, % FPβC percentage of functional pancreatic beta cells, SBP systolic blood pressure, DBP diastolic blood pressure, VLDL very low density lipoprotein, uOC undercarboxylated osteocalcin, cOC carboxylated osteocalcin, BMI body mass index. Data presented in average and standard deviation. Statistically significant data are shown in italics type (p < 0.05)