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Table 4 Pre-treatment vs post-treatment comparison of clinical and biochemical parameters in T2DM patients with vitamin K2 supplementation

From: Effect of supplementation with vitamins D3 and K2 on undercarboxylated osteocalcin and insulin serum levels in patients with type 2 diabetes mellitus: a randomized, double-blind, clinical trial

Variable

Initial N = 12

Final N = 12

p value

Glucose (mg/dL)

130 ± 29

114 ± 35

0.002

HOMA-IR

4.1 ± 2.8

2.8 ± 1.9

0.041

%FPβc

514 ± 204

174 ± 104

0.002

SBP (mmHg)

132 ± 27

130 ± 18

0.695

DBP (mmHg)

81 ± 14

78 ± 8

0.116

Cholesterol (mg/dL)

197 ± 41

206 ± 34

0.239

Triglycerides (mg/dL)

180 ± 115

188 ± 79

0.814

VLDL (mg/dL)

36 ± 23

37 ± 15

0.814

uOC (ng/dlL

2.5 ± 1.6

2.3 ± 1.2

0.638

cOC (ng/dL

0.818 ± 0.567

1.2 ± 1.1

0.041

uOC/cOC index

4.3 ± 4.2

2.7 ± 1.9

0.182

Insulin (ng/dL)

108 ± 54

85 ± 43

0.117

Muscle (%)

46 ± 9

46 ± 10

0.657

Fat (%)

34 ± 9

34 ± 9

0.875

BMI (kg/m2)

28 ± 7

28 ± 7

1.000

Weight (kg)

76 ± 20

75 ± 20

1.000

  1. HOMA-IR homeostatic model assessment-insulin resistance, % FPβC percentage of functional pancreatic beta cells, SBP systolic blood pressure, DBP diastolic blood pressure, VLDL very low density lipoprotein, uOC undercarboxylated osteocalcin, cOC carboxilated osteocalcin, BMI body mass index. Data presented in average and standard deviation. Statistically significant data are shown in italics type (p < 0.05)