From: Potential roles of psychological and oxidative stress in insulin resistance: a cohort-based study
Variable | Insulin resistance | No insulin resistance | p |
---|---|---|---|
N (F) | 122 (7) | 112 (12) | Â |
Age; years | 41.00 (39.62, 42.38) | 40.00 (38.52, 41.47) | 0.39 |
Metabolic syndrome; n (%) | 86 (67.71) | 24 (21.42%) | < 0.0001 |
Atherogenic dyslipidemia; n (%) | 36 (28.35) | 9 (8.03) | 0.0001 |
FRS | 5.40 (4.26, 6.53) | 3.20 (2.22, 4.17) | 0.0001 |
BMI; kg/m2 | 31.44 (30.55, 32.32) | 27.75 (26.95, 28.55) | < 0.0001 |
W/H ratio | 0.977 (0.973, 0.990) | 0.91 (0.895, 0.926) | < 0.0001 |
Overweight; n (%) | 44 (34.64) | 58 (51.78) | 0.01 |
Obesity; n (%) | 78 (61.42) | 25 (23.21) | < 0.0001 |
Stable CHD, n (%) | 13 (10.23%) | 4 (3.57%) | 0.06 |
Coronary plaque; n (%)a | 32 (33.33) | 13 (21.31) | 0.11 |
Hypertension; n(%) | 87 (71.31) | 49 (43.75) | < 0.0001 |
Current smoking; n (%) | 42 (33.07) | 35 (31.25) | 0.98 |
Total cholesterol; mmol/L | 5.40 (5.18, 5.61) | 5.05 (4.81, 5.28) | 0.08 |
LDL cholesterol; mmol/L | 3.12 (2.94, 3.30) | 2.99 (2.80, 3.17) | 0.32 |
HDL cholesterol; mmol/L | 1.20 (1.15, 1.24) | 1.29 (1.25, 1.34) | 0.01 |
Triglycerides, mmol/L | 2.05 (1.68, 2.42) | 1.34 (1.05, 1.62) | < 0.001 |
Glucose; mmol/L | 5.40 (5.24, 5.57) | 5.10 (4.99, 5.20) | < 0.0001 |
ALT; U/L | 44.00 (40,49, 49.50) | 38.00 (32,82, 39.77) | 0.002 |
AST; U/L | 34.00 (31.89, 36.90) | 30.00 (28.07, 31.37) | 0.002 |
Total bilirubin; µmol/L | 12.00 (10.42, 13.57) | 13.00 (11.53, 14.46) | 0.16 |
Uric acid; µmol/L | 378.00 (359.61, 396.38) | 334.50 (315.95, 353.04) | < 0.0001 |
Serum creatinine; µmol/L | 91.00 (87.78, 94.21) | 89.00 (85.84, 92.15) | 0.30 |
SBP; mm Hg | 135.00 (131.40, 138.66) | 120.00 (115.92, 124.07) | < 0.0001 |
DBP; mm Hg | 85.00 (82.65, 87.35) | 80.00 (76.56, 82.43) | 0.0009 |
cIMT; mm | 0.56 (0.550, 0.571) | 0.54 (0.535, 0.547) | 0.001 |
FMD; % | 7.08 (6.30, 7.85) | 7.57 (6.75, 8.38) | 0.31 |
CRP; mg/L | 1.29 (1.229, 1.36) | 0.88 (0.53, 1.23) | 0.0001 |
TNF-α; pg/mL | 0.92 (0.90, 0.94) | 0.82 (0.74, 0.89) | 0.02 |
Fibrinogen; g/L | 3.30 (3.11, 3.48) | 3.20 (3.01, 3.38) | 0.61 |
Insulin; µIU/mL | 23.82 (20.10, 27.54) | 11.37 (10.55, 12.18) | < 0.0001 |
HOMA-IR | 3.02 (2.78, 3.26) | 1.46 (1.35, 1.56) | < 0.0001 |
Plasma 8-iso-PGF2α; pg/mL | 7.60 (6.55, 8.03) | 6.39 (5.21, 6,56) | 0.04 |
Urine cortisol; ng/mg of creatinine | 119.70 (105.01, 134.40) | 89.80 (76.90, 102.69) | < 0.001 |
PSS-10 score | 17.00 (15.73, 18.27) | 16.0 (14.86, 17.30) | 0.62 |
Medications, n (%) | |||
Aspirin | 1 (0.82) | 5 (4.46) | 0.07 |
 ACEI/ARB | 31 (25.40) | 10 (8.93) | 0.001 |
 β-blocker | 28 (22.95) | 12 (10.71) | 0.01 |
 Ca-blocker | 10 (8.10) | 3 (2.68) | 0.05 |
 Diuretics | 22 (18.03) | 5 (4.46) | 0.001 |
 Lipid-lowering agents | 7 (5.74) | 4 (3.57) | 0.43 |