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Table 3 Comparison of insulin resistance and β-cell function among groups divided by LFC quartile

From: Association of [1H]-MRS quantified liver fat content with glucose metabolism status

ParametersLFC < 5.89%
(n = 61)
5.89% ≤ LFC < 11.62%
(n = 61)
11.62% ≤ LFC < 16.26%
(n = 60)
16.26% ≤ LFC
(n = 60)
p value
FPG (mmol/l)5.26 ± 1.006.28 ± 1.35a6.99 ± 1.36bd7.45 ± 1.09ce0.000
2hPG (mmol/l)6.70 (5.73, 9.59)10.42 (8.01, 17.16)a15.23 (10.49, 17.68)b16.89 (12.90, 17.86)ce0.000
Delta G304.23 ± 1.415.52 ± 1.59a5.60 ± 1.58b5.51 ± 1.58c0.000
Delta Ins3039.96 (18.02, 56.95)24.03 (12.28, 47.62)13.70 (5.87, 31.97)b10.60 (4.67, 23.61)ce0.000
Delta C302.69 (1.80, 4.27)2.09 (1.10, 3.79)1.40 (0.63, 2.80)b1.05 (0.71, 1.78)ce0.000
Ins30/G30 AUC9.26 (4.49, 14.24)4.49 (2.17, 9.55)a2.36 (1.01, 6.39)b2.11 (0.84, 4.08)ce0.000
CP30/G30 AUC0.65 (0.38, 1.06)0.38 (0.19, 0.81)a0.28 (0.12, 0.52)b0.21 (0.11, 0.33)ce0.000
Ins AUC/G AUC5.52 (3.52, 7.79)3.20 (1.33, 5.24)a1.86 (1.20, 4.50)b1.51 (1.04, 3.56)ce0.000
CP AUC/G AUC0.57 (0.38, 0.85)0.44 (0.22, 0.70)0.31 (0.19, 0.55)b0.29 (0.17, 0.43)c0.000
HOMA-IR1.62 ± 0.581.98 ± 0.762.31 ± 0.78b2.64 ± 1.14ce0.000
HOMA-β93.38 (56.90, 141.29)55.61 (32.92, 94.99)a40.48 (25.21, 78.90)b34.74 (26.58, 56.84)c0.000
Matsuda ISI110.23 ± 42.9195.46 ± 38.5588.92 ± 34.31b85.69 ± 36.26c0.005
  1. AUC area under the curve, PG plasma glucose, FPG fasting plasma glucose, HOMA-IR homeostatic model assessment of insulin resistance, HOMR-β homeostatic model assessment for β-cell function, LFC liver fat content, Matsuda ISI Matsuda insulin sensitivity index
  2. aSignificant difference in LFC < 5.89% versus 5.89% ≤ LFC < 11.62
  3. bSignificant difference in LFC < 5.89% versus 11.62% ≤ LFC < 16.26%
  4. cSignificant difference in LFC < 5.89% versus 16.26% ≤ LFC
  5. dSignificant difference in 5.89% ≤ LFC < 11.62 versus 11.62% ≤ LFC < 16.26%
  6. eSignificant difference in 5.89% ≤ LFC < 11.62 versus 16.26% ≤ LFC
  7. fSignificant difference in 11.62% ≤ LFC < 16.26% versus 16.26% ≤ LFC