Changes of circulating neuregulin 4 and its relationship with 25-hydroxy vitamin D and other diabetic vascular complications in patients with diabetic peripheral neuropathy

Table 3 Linear correlation and multiple regression analysis of variables associated with circulating Nrg4 in study subjects

Variable	Simple				Multiple
Variable	R	P-value	Adjusted r	Adjusted P-value	β	Standardized β	P-value
Sex	0.125	0.110	–	–
Age	0.075	0.340	–	–
BMI	− 0.165	0.035	–	–
SBP	0.115	0.142	0.125	0.114	0.021	0.150	0.034
DBP	0.083	0.290	0.104	0.190
FBG	− 0.123	0.116	− 0.077	0.329
PBG	− 0.032	0.680	− 0.017	0.834
HbA1c	0.035	0.653	0.031	0.697
FIns	0.010	0.894	0.006	0.937
HOMA-IR	− 0.061	0.440	− 0.032	0.690
TC	0.110	0.159	0.105	0.184
TG	− 0.034	0.661	0.042	0.598
HDL-C	0.148	0.059	0.109	0.169
LDL-C	0.117	0.136	0.113	0.155	0.245	0.149	0.035
UACR	0.122	0.120	0.103	0.19
eGFR	− 0.078	0.322	− 0.076	0.337
Scr	− 0.005	0.947	0.058	0.469
25(OH)D	0.194	0.013	0.240	0.002	0.070	0.220	0.002
ABI	− 0.011	0.893	0.000	0.997
VPT	− 0.412	0.000	− 0.360	0.000	− 0.059	− 0.372	0.000
DPN	− 0.276	0.000	− 0.218	0.005
VPT > 25 V	− 0.506	0.000	− 0.433	0.000
Abnormal prickingsensation	− 0.078	0.322	0.130	0.100
Abnormal nylon monofilament	0.017	0.832	− 0.079	0.319
Reflex abnormalities	− 0.116	0.139	− 0.067	0.401
DN	0.000	0.999	0.045	0.571
DR	0.003	0.972	0.014	0.864
PAD	0.055	0.485	0.010	0.896

In multiple linear stepwise regression analysis, values included for analysis in nT2DM patients were sex, age, BMI, SBP, DBP, FBG, PBG, HbA1C, FIns, HOMA-IR, TG, TC, HDL-C, LDL-C, UACR, eGFR, Scr, 25(OH)D, ABI, and VPT

ISSN: 1758-5996