Adipose tissue gene expression of long non-coding RNAs; MALAT1, TUG1 in obesity: is it associated with metabolic profile and lipid homeostasis-related genes expression?

Table 5 Unadjusted and adjusted correlation of MALAT1 gene expression in SAT and VAT of the whole population study with energy homeostasis-related genes

Characteristics	lncRNA MALAT1 in SAT		lncRNA MALAT1 in VAT
	Whole Population		Whole Population
	Unadjusted Pearson coefficient	Adjusted for age and HOMA-IR Pearson coefficient	Unadjusted Pearson coefficient	Adjusted for age and HOMA-IR Pearson coefficient
PPARγ	0.329^a	0.299	0.070	0.086
PGC1α	0.153	0.250	0.455^b	0.424^b
SREBP	0.640^b	0.589^b	0.225	0.193
FAS	0.573^b	0.513^b	0.261	0.210
ACC	0.411^b	0.401^b	0.186	0.153
LncRNA TUG1	0.299	0.346^a	− 0.380^a	− 0.324^a

SAT, subcutaneous adipose tissue; VAT, visceral adipose tissue; MALAT1, metastasis-associated lung adenocarcinoma transcript 1; TUG1, taurine upregulated gene 1; PPARγ, peroxisome proliferator-activated receptor gamma; PGC1α, PPARγ coactivator-1 alpha; SREBP-1, sterol regulatory element-binding protein α; FAS, fatty acid synthase; ACC, acetyl-CoA carboxylase; HOMA-IR, homeostasis model assessment of insulin resistance
^a Correlation is significant at the 0.05 level (2-tailed)
^b Correlation is significant at the 0.01 level (2-tailed)

ISSN: 1758-5996