Adipose tissue gene expression of long non-coding RNAs; MALAT1, TUG1 in obesity: is it associated with metabolic profile and lipid homeostasis-related genes expression?

Table 3 Unadjusted and adjusted correlation of MALAT1 gene expression in SAT and VAT of the whole population study with anthropometric and metabolic profiles

Characteristics	lncRNA MALAT1 in SAT		lncRNA MALAT1 in VAT
	Whole population		Whole population
	Unadjusted Pearson coefficient	Adjusted for age and HOMA-IR Pearson coefficient	Unadjusted Pearson coefficient	Adjusted for age and HOMA-IR Pearson coefficient
BMI, kg/m²	0.149	− 0.187	0.210	0.358
WC, cm	0.062	− 0.332	0.180	0.278
Hip, cm	0.133	− 0.213	0.237	0.347
WHR, -	− 0.182	− 0.264	− 0.113	− 0.072
FBG, mg/dL	0.273	0.210	0.091	0.090
Creatinine, mg/dL	0.107	0.102	− 0.023	− 0.074
eGFR, mL/min/1.73 m²	− 0.094	0.096	0.047	0.092
HDL-C, mg/dL	− 0.157	− 0.149	0.233	0.229
LDL-C, mg/dL	0.264	0.068	0.167	0.159
TC, mg/dL	0.166	− 0.082	0.238	0.258
TG, mg/dL	0.041	0.069	0.100	0.054
hs-CRP, mg/L	0.205	0.004	− 0.103	− 0.208
HOMA-IR, -	0.319^a	–	0.046	–
Insulin, µU/mL	0.288	–	0.032	–

BMI, body mass index; WC, waist circumference; WHR, waist-to-hip ratio; FBG, fasting blood glucose; HDL-high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; TC, total cholesterol; TG, triglycerides; hs-CRP, high-sensitivity C-reactive Protein; HOMA-IR, homeostasis model assessment of insulin resistance; eGFR, estimated glomerular filtration rate
^a Correlation is significant at the 0.05 level (2-tailed)

ISSN: 1758-5996