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Table 2 Comparison of liver function before and after treatment with DPP-4 inhibitors

From: Evaluation of efficacy and safety of DPP-4 inhibitors for Chinese elderly patients with type 2 diabetes mellitus

Index

Groups

Before treatment

After treatment

The change (ΔA)

P

ALT

All patients

22.62 ± 10.33

20.21 ± 8.31

− 2.4

< 0.001

AST

All patients

25.83 ± 8.70

22.38 ± 10.29

− 3.4

< 0.001

GGT

All patients

29.82 ± 17.42

30.52 ± 22.55

0.7

0.567

ALT

Medication time ≤ 12

22.52 ± 8.44

22.58 ± 10.22

+ 0.07

0.955

Medication time > 12

22.79 ± 10.84

19.75 ± 7.62

− 3.05

< 0.001

AST

Medication time ≤ 12

23.72 ± 6.55

23.85 ± 7.85

− 0.13

0.884

Medication time > 12

26.57 ± 9.17

22.12 ± 10.94

− 4.45

< 0.001

GGT

Medication time ≤ 12

27.89 ± 13.96

28.14 ± 18.39

− 0.26

0.865

Medication time > 12

30.19 ± 18.06

31.07 ± 23.35

+ 0.88

0.537

ALT

eGFR ≥ 90 mL/min/1.73 m2

23.74 ± 9.12

20.94 ± 7.78

− 2.80

< 0.001

eGFR < 90 mL/min/1.73 m2

21.96 ± 10.93

19.83 ± 8.62

− 2.13

< 0.001

AST

eGFR ≥ 90 mL/min/1.73 m2

25.41 ± 6.76

22.70 ± 8.45

− 2.71

< 0.001

eGFR < 90 mL/min/1.73 m2

26.10 ± 9.63

22.24 ± 11.22

− 3.86

< 0.001

GGT

eGFR ≥ 90 mL/min/1.73 m2

33.80 ± 21.78

32.64 ± 24.86

− 1.16

0.561

eGFR < 90 mL/min/1.73 m2

28.13 ± 14.91

29.66 ± 21.53

1.54

0.315