From: Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations
Amino acids (μmol/L) | IS (n = 48) (mean ± SD) | IR (n = 106) (mean ± SD) | T2D (n = 67) (mean ± SD) | HOMA-IR# (r values) |
---|---|---|---|---|
Individual amino acids | ||||
Alanine (Ala) | 291 ± 73 | 318 ± 81 | 338 ± 107a | 0.22* |
Arginine (Arg) | 55.0 ± 14.4 | 55.6 ± 12.2 | 49.7 ± 12.9a,b | 0.08 |
Asparagine (Asn) | 39.9 ± 6.6 | 37.2 ± 6.4a | 38.1 ± 7.4 | − 0.21* |
Aspartic acid (Asp) | 5.42 ± 2.52 | 5.42 ± 1.99 | 5.71 ± 1.88 | 0.10 |
Citrulline (Cit) | 26.5 ± 4.6 | 24.1 ± 5.0a | 23.3 ± 6.7a | − 0.21* |
Cysteine (Cys) | 4.26 ± 2.36 | 4.77 ± 2.18 | 4.80 ± 2.19 | 0.19* |
Glutamine (Gln) | 526 ± 104 | 509 ± 80 | 469 ± 81a,b | − 0.06 |
Glutamic acid (Glu) | 64.8 ± 36.4 | 83.1 ± 36.6a | 84.6 ± 21.4a | 0.32** |
Glycine (Gly) | 213 ± 43 | 184 ± 41a | 179 ± 58a | − 0.26* |
Histidine (His) | 91.0 ± 14.2 | 89.5 ± 14.6 | 83.4 ± 16.7a,b | − 0.03 |
Isoleucine (Ile) | 65.6 ± 16.8 | 70.4 ± 15.2 | 75.2 ± 21.8a | 0.25* |
Leucine (Leu) | 123 ± 24 | 135 ± 24a | 145 ± 39a | 0.29** |
Lysine (Lys) | 149 ± 28 | 152 ± 29 | 155 ± 34 | 0.12 |
Methionine (Met) | 21.1 ± 2.6 | 21.6 ± 2.9 | 20.8 ± 3.8 | 0.16* |
Ornithine (Orn) | 47.4 ± 12.7 | 45.3 ± 11.7 | 47.0 ± 15.5 | − 0.04 |
Phenylalanine (Phe) | 42.9 ± 7.4 | 46.5 ± 7.3a | 47.5 ± 8.3a | 0.24* |
Proline (Pro) | 186 ± 48 | 204 ± 52a | 205 ± 64 | 0.18* |
Serine (Ser) | 76.4 ± 15.7 | 70.6 ± 12.1a | 73.9 ± 15.1 | − 0.07 |
Threonine (Thr) | 99.8 ± 18.3 | 92.1 ± 16.6a | 94.0 ± 23.4 | − 0.13 |
Tryptophane (Trp) | 56.9 ± 14.8 | 58.0 ± 13.2 | 55.8 ± 12.0 | 0.11 |
Tyrosine (Tyr) | 49.5 ± 10.0 | 57.0 ± 10.5a | 56.4 ± 13.1a | 0.43** |
Valine (Val) | 241 ± 46 | 261 ± 59a | 259 ± 75 | 0.21* |
Amino acid class | ||||
Aromatic | 240 ± 32 | 251 ± 27a | 243 ± 36 | 0.27** |
Branched-chain | 430 ± 76 | 466 ± 92a | 479 ± 129a | 0.25* |
Citrulline precursors | 879 ± 134 | 897 ± 109 | 856 ± 133b | 0.11 |
Total amino acids | 2517 ± 251 | 2530 ± 296 | 2518 ± 411 | 0.09 |
Amino acid ratios | ||||
Citrulline/amino acids | 0.011 ± 0.002 | 0.010 ± 0.002a | 0.009 ± 0.003a | − 0.22* |
Citrulline/precursors | 0.031 ± 0.009 | 0.027 ± 0.006a | 0.028 ± 0.008a | 0.25* |
Arg bioavailability | 0.77 ± 0.24 | 0.83 ± 0.21 | 0.74 ± 0.21b | 0.11 |
NO activity | 0.51 ± 0.15 | 0.45 ± 0.12a | 0.49 ± 0.21 | 0.13 |
Arginase activity | 0.96 ± 0.49 | 0.86 ± 0.34 | 1.02 ± 0.58b | − 0.05 |
Arginase/NO activity | 1.83 ± 0.56 | 1.97 ± 0.78 | 2.14 ± 0.88a | 0.13 |