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Table 2 Plasma amino acid profile in men (n = 221)

From: Plasma biomarkers of small intestine adaptations in obesity-related metabolic alterations

Amino acids (μmol/L)

IS (n = 48) (mean ± SD)

IR (n = 106) (mean ± SD)

T2D (n = 67) (mean ± SD)

HOMA-IR# (r values)

Individual amino acids

Alanine (Ala)

291 ± 73

318 ± 81

338 ± 107a

0.22*

Arginine (Arg)

55.0 ± 14.4

55.6 ± 12.2

49.7 ± 12.9a,b

0.08

Asparagine (Asn)

39.9 ± 6.6

37.2 ± 6.4a

38.1 ± 7.4

− 0.21*

Aspartic acid (Asp)

5.42 ± 2.52

5.42 ± 1.99

5.71 ± 1.88

0.10

Citrulline (Cit)

26.5 ± 4.6

24.1 ± 5.0a

23.3 ± 6.7a

− 0.21*

Cysteine (Cys)

4.26 ± 2.36

4.77 ± 2.18

4.80 ± 2.19

0.19*

Glutamine (Gln)

526 ± 104

509 ± 80

469 ± 81a,b

− 0.06

Glutamic acid (Glu)

64.8 ± 36.4

83.1 ± 36.6a

84.6 ± 21.4a

0.32**

Glycine (Gly)

213 ± 43

184 ± 41a

179 ± 58a

− 0.26*

Histidine (His)

91.0 ± 14.2

89.5 ± 14.6

83.4 ± 16.7a,b

− 0.03

Isoleucine (Ile)

65.6 ± 16.8

70.4 ± 15.2

75.2 ± 21.8a

0.25*

Leucine (Leu)

123 ± 24

135 ± 24a

145 ± 39a

0.29**

Lysine (Lys)

149 ± 28

152 ± 29

155 ± 34

0.12

Methionine (Met)

21.1 ± 2.6

21.6 ± 2.9

20.8 ± 3.8

0.16*

Ornithine (Orn)

47.4 ± 12.7

45.3 ± 11.7

47.0 ± 15.5

− 0.04

Phenylalanine (Phe)

42.9 ± 7.4

46.5 ± 7.3a

47.5 ± 8.3a

0.24*

Proline (Pro)

186 ± 48

204 ± 52a

205 ± 64

0.18*

Serine (Ser)

76.4 ± 15.7

70.6 ± 12.1a

73.9 ± 15.1

− 0.07

Threonine (Thr)

99.8 ± 18.3

92.1 ± 16.6a

94.0 ± 23.4

− 0.13

Tryptophane (Trp)

56.9 ± 14.8

58.0 ± 13.2

55.8 ± 12.0

0.11

Tyrosine (Tyr)

49.5 ± 10.0

57.0 ± 10.5a

56.4 ± 13.1a

0.43**

Valine (Val)

241 ± 46

261 ± 59a

259 ± 75

0.21*

Amino acid class

Aromatic

240 ± 32

251 ± 27a

243 ± 36

0.27**

Branched-chain

430 ± 76

466 ± 92a

479 ± 129a

0.25*

Citrulline precursors

879 ± 134

897 ± 109

856 ± 133b

0.11

Total amino acids

2517 ± 251

2530 ± 296

2518 ± 411

0.09

Amino acid ratios

Citrulline/amino acids

0.011 ± 0.002

0.010 ± 0.002a

0.009 ± 0.003a

− 0.22*

Citrulline/precursors

0.031 ± 0.009

0.027 ± 0.006a

0.028 ± 0.008a

0.25*

Arg bioavailability

0.77 ± 0.24

0.83 ± 0.21

0.74 ± 0.21b

0.11

NO activity

0.51 ± 0.15

0.45 ± 0.12a

0.49 ± 0.21

0.13

Arginase activity

0.96 ± 0.49

0.86 ± 0.34

1.02 ± 0.58b

− 0.05

Arginase/NO activity

1.83 ± 0.56

1.97 ± 0.78

2.14 ± 0.88a

0.13

  1. Citrulline precursors: Arg, Orn, Gln, Glu and Pro; Arg bioavailability: Arg/(Orn + Cit); NO activity: Cit/Arg; arginase activity: Orn/Arg; arginase/NO activity: Orn/Cit
  2. ap < 0.05 vs IS; bp < 0.05 vs IR #Pearson correlation coefficient adjusted for age and GFR; *p < 0.05; **p < 0.001