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Table 1 Circulating TBIL levels and other clinical characteristics between T2DM patients with and without DPN

From: Physiological serum total bilirubin concentrations were inversely associated with diabetic peripheral neuropathy in Chinese patients with type 2 diabetes: a cross-sectional study

Variables

No DPN

DPN

P-value

(n = 1129)

(n = 213)

Male/female (n)

522/607

116/97

0.027

Age (years)

58.94 ± 10.74

66.65 ± 9.90

0.000

BMI (kg/m2)

24.17 ± 3.57

23.42 ± 3.99

0.003

Diabetic duration (years)

7.30 ± 6.16

10.61 ± 7.46

0.000

SBP (mmHg)

131.96 ± 20.38

135.63 ± 22.63

0.016

DBP (mmHg)

71.95 ± 11.93

70.04 ± 12.88

0.034

PP(mmHg)

60.03 ± 18.37

65.59 ± 19.32

0.000

MAP(mmHg)

91.96 ± 12.60

91.91 ± 14.09

0.958

FBG (mmol/L)

10.62 ± 5.15

11.53 ± 5.45

0.005

HbA1c (%)

9.38 ± 2.49

10.12 ± 2.63

0.000

TC (mmol/L)

4.91 ± 1.34

4.67 ± 1.29

0.011

TG (mmol/L)

2.37 ± 2.44

1.87 ± 1.38

0.002

HDL-C (mmol/L)

1.18 ± 0.35

1.18 ± 0.37

0.445

LDL-C (mmol/L)

2.81 ± 1.01

2.76 ± 0.97

0.503

ApoA (g/L)

1.35 ± 0.29

1.27 ± 0.33

0.000

ApoB (g/L)

0.91 ± 0.28

0.91 ± 0.36

0.591

ApoB/ApoA

0.70 ± 0.25

0.76 ± 0.36

0.026

TBIL (μmol/L)

11.63 ± 3.87

10.02 ± 3.61

0.000

TBIL (μmol/L)a

11.62 ± 3.86

9.96 ± 3.60

0.000

DBIL (μmol/L)

4.08 ± 1.46

3.70 ± 1.39

0.000

IBIL (μmol/L)

7.55 ± 2.92

6.32 ± 2.65

0.000

ALT (U/L)

19.40 ± 9.00

15.65 ± 8.02

0.000

AST (U/L)

18.93 ± 6.09

17.37 ± 6.14

0.000

Neutrophil count (* 109/L)

4.42 ± 2.01

5.34 ± 2.85

0.000

Lymphocyte count (* 109/L)

1.68 ± 0.63

1.46 ± 0.57

0.000

NLR

3.10 ± 2.58

4.40 ± 4.00

0.000

WBC (* 109/L)

6.65 ± 2.18

7.41 ± 3.03

0.000

PT (s)

12.44 ± 1.15

13.12 ± 2.00

0.000

APTT (s)

31.36 ± 5.93

33.26 ± 8.60

0.007

INR

1.02 ± 0.08

1.07 ± 0.19

0.001

Fibrinogen (g/L)

3.55 ± 1.23

4.43 ± 1.59

0.000

ACR (mg/g)

212.59 ± 24.67

445.13 ± 73.42

0.000

eGFR (mL/min/1.73 m2)

93.80 ± 25.11

77.72 ± 27.45

0.000

Crea (μmol/L)

71.05 ± 45.82

88.25 ± 50.21

0.000

VPT (V)

13.03 ± 4.72

36.67 ± 8.88

0.000

ABI

1.03 ± 0.13

0.95 ± 0.24

0.000

Hypertension (n, %)

565 (50.04)

135 (63.38)

0.000

CHD (n, %)

87 (7.71)

37 (17.37)

0.000

Stroke (n, %)

213 (18.87)

71 (33.33)

0.000

DFU (n, %)

54 (4.78)

47 (22.07)

0.000

PAD (n, %)

80 (7.09)

57 (26.76)

0.000

DN (n, %)

385 (34.10)

113 (53.05)

0.000

DR (n, %)

128 (11.34)

47 (22.07)

0.000

  1. Data are mean ± SD
  2. SD standard deviation, DPN diabetic peripheral neuropathy, BMI body mass index, SBP systolic blood pressure, DBP diastolic blood pressure, PP pulse pressure, MAP mean arterial pressure, FBG fasting blood glucose, HbA1c glycated hemoglobin A1c, TC total cholesterol, TG triglyceride, HDL-C high-density lipoprotein cholesterol, LDL-C low-density lipoprotein cholesterol, apoA apolipoprotein A, apoB apolipoprotein B, ApoB/ApoA apolipoprotein B–apolipoprotein A ratio, TBIL total bilirubin, DBIL direct bilirubin, IBIL indirect bilirubin, ALT alanine aminotransferase, AST aspartate aminotransferase, NLR neutrophil to lymphocyte ratio, WBC white blood cell, PT prothrombin time, APTT activated partial thromboplastin time, INR international normalized ration, ACR albumin- to-creatinine ratio, eGFR estimated glomerular filtration rate, Crea creatinine, VPT vibration perception threshold, ABI ankle–brachial index, CHD coronary heart disease, DFU diabetic foot ulceration, PAD peripheral arterial disease, DN diabetic nephropathy, DR diabetic retinopathy
  3. aAdjustment for age, sex, BMI, and diabetic duration performed with analysis of covariance (ANCOVA) (dependent variable: serum TBIL level, fixed factor: group, and covariates: age, sex, BMI, and diabetic duration)
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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