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Table 4 Biochemical markers and appetite in the Zinc and Placebo groups

From: Zinc supplementation improves body weight management, inflammatory biomarkers and insulin resistance in individuals with obesity: a randomized, placebo-controlled, double-blind trial

VariablesZinc groupPlacebo groupp-value
BaselineWeek 15Mean changeBaselineWeek 15Mean changeP2P3P4P5
Zinc (µg/dL)165.2 ± 5.975.4 ±  8.210.2 ±  6.871.15 ± 13.268.15 ± 10− 3  ± 13.10.0860.0180.00010.002
P10.00010.296
hs-CRP (mg/L)15.27 ± 2.93b3.37 ± 2.24− 1.89 ± 1.604.75 ± 2.283.98 ± 2.04− 0.07 ± 1.80.1240.0640.00010.0001
P10.00010.60
TNF-α (pg/ml) 232.41 (10.92, 708.48) a30.43 (11.79, 546.19)− 1.9826.07 (13.19, 67.47)25.07 (9.62, 94.65)− 1.00.1700.2380.2930.723
P10.4730.451
Apelin (pg/ml)21568.20 (1119, 3282)1245.13 (482, 2087)− 323.071493.45 (505, 4467)1683.32 (963, 3804)189.870.8050.0170.0020.001
P10.0420.001
FBS (mg/dL)186.83 ± 11.9483.50 ± 7.36− 3.33 ± 6.5686.90 ± 9.9386.90 ± 13.420.00 ± 6.000.9830.3430.1020.088
P10.0461.00
Insulin (microU/L)25.91 (1.7,18.60)4.05 (1,9.1)− 1.865.07 (1.8, 22.6)5.08 (1.7, 27.2)0.010.1350.330.0190.073
P10.0020.735
HOMA-IR21.35 (0.37, 2.81)0.83 (0.21, 2.27)− 0.521.02 (0.41, 5.88)1.08 (0.33, 9.27)0.060.1600.2940.0110.031
P10.00010.757
NPY (ng/l)2306.1 (178.8, 1540.5)273.8 (170.1, 1022.8)− 32.27400.9 (198.9, 2239.2)411.6 (180.6, 1900.9)10.720.1470.0370.0480.151
P10.1140.243
Appetite116.00 ± 2.1113.77 ± 2.36− 2.22 ± 2.8115.50 ± 1.8015.45 ± 1.59− 0.04 ± 1.590.4260.0110.0070.001
P10.0040.892
  1. aValues are geometric mean (minimum, maximum)
  2. bValues are mean ± SD
  3. P1: p-values for comparison of variables within groups by Paired T-test
  4. P2: p-values for comparison of variables between two groups by independent T-test at baseline
  5. P3: p-values for comparison of variables between two group by independent T-test at week15
  6. P4: p-values for comparison of mean change of variables between two group by independent T-test
  7. P5: p-values for comparison between mean changes of variables by Analysis of covariance (adjusted for age, and mean change of calorie intake)