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Table 3 PI3K/Akt signaling related genes

From: Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity

Gene symbolProbeset IDCpG locationp-value (Ob vs. L)Methylation difference (Ob − L)Probeset IDp-value (Ob vs. L)Fold change
BCL2cg07111678aTSS15000.04−0.33203685_at0.042.5
JAK1cg25020373aTSS2000.01−0.70240613_at0.032.4
MAP3K8cg03807314bTSS2000.04−0.19235421_at0.041.9
PPP2R1Bcg09085632aTSS2000.045.62222351_at0.02−2.3
PPP2R2Ccg23195028bBody0.013.31223573_s_at0.01−4.6
PPP2R3Acg24636867aTSS2000.04−0.34207749_s_at0.022.6
PPP2R5Cccg18997701bBody0.02−0.291557718_at0.012.2
PTENcg08602305a5′UTR0.03−0.31233254×_at0.026.1
SYNJ2cg03682872aTSS2000.03−0.35216180_s_at0.041.5
THEM4cg03147210aTSS2000.05−0.52229253_at0.031.7
TFAMccg03859893bTSS2000.05−1.02238443_at0.052.5
  1. Data are presented as mean ± SD
  2. Methylation Difference:  % Methylation (Ob)- % Methylation (L); values for  % methylation of groups are located in Additional file 4: Table S4. Significant probes from global DNA methylation analysis and global gene expression analysis were overlaid for matching genes; Probeset ID represents a single gene that may contain multiple methylation (CpG) sites. IPA Canonical Pathway tool identified PI3K/AKT Signaling as significantly overrepresented in our significant gene list
  3. aInfinium I probe design
  4. bInfinium II probe design
  5. cIndicates genes validated via qPCR. Gene names are located in Additional file 4: Table S4