Skip to main content

Table 3 PI3K/Akt signaling related genes

From: Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity

Gene symbol

Probeset ID

CpG location

p-value (Ob vs. L)

Methylation difference (Ob − L)

Probeset ID

p-value (Ob vs. L)

Fold change

BCL2

cg07111678a

TSS1500

0.04

−0.33

203685_at

0.04

2.5

JAK1

cg25020373a

TSS200

0.01

−0.70

240613_at

0.03

2.4

MAP3K8

cg03807314b

TSS200

0.04

−0.19

235421_at

0.04

1.9

PPP2R1B

cg09085632a

TSS200

0.04

5.62

222351_at

0.02

−2.3

PPP2R2C

cg23195028b

Body

0.01

3.31

223573_s_at

0.01

−4.6

PPP2R3A

cg24636867a

TSS200

0.04

−0.34

207749_s_at

0.02

2.6

PPP2R5Cc

cg18997701b

Body

0.02

−0.29

1557718_at

0.01

2.2

PTEN

cg08602305a

5′UTR

0.03

−0.31

233254×_at

0.02

6.1

SYNJ2

cg03682872a

TSS200

0.03

−0.35

216180_s_at

0.04

1.5

THEM4

cg03147210a

TSS200

0.05

−0.52

229253_at

0.03

1.7

TFAMc

cg03859893b

TSS200

0.05

−1.02

238443_at

0.05

2.5

  1. Data are presented as mean ± SD
  2. Methylation Difference:  % Methylation (Ob)- % Methylation (L); values for  % methylation of groups are located in Additional file 4: Table S4. Significant probes from global DNA methylation analysis and global gene expression analysis were overlaid for matching genes; Probeset ID represents a single gene that may contain multiple methylation (CpG) sites. IPA Canonical Pathway tool identified PI3K/AKT Signaling as significantly overrepresented in our significant gene list
  3. aInfinium I probe design
  4. bInfinium II probe design
  5. cIndicates genes validated via qPCR. Gene names are located in Additional file 4: Table S4