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Table 3 PI3K/Akt signaling related genes

From: Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity

Gene symbol Probeset ID CpG location p-value (Ob vs. L) Methylation difference (Ob − L) Probeset ID p-value (Ob vs. L) Fold change
BCL2 cg07111678a TSS1500 0.04 −0.33 203685_at 0.04 2.5
JAK1 cg25020373a TSS200 0.01 −0.70 240613_at 0.03 2.4
MAP3K8 cg03807314b TSS200 0.04 −0.19 235421_at 0.04 1.9
PPP2R1B cg09085632a TSS200 0.04 5.62 222351_at 0.02 −2.3
PPP2R2C cg23195028b Body 0.01 3.31 223573_s_at 0.01 −4.6
PPP2R3A cg24636867a TSS200 0.04 −0.34 207749_s_at 0.02 2.6
PPP2R5Cc cg18997701b Body 0.02 −0.29 1557718_at 0.01 2.2
PTEN cg08602305a 5′UTR 0.03 −0.31 233254×_at 0.02 6.1
SYNJ2 cg03682872a TSS200 0.03 −0.35 216180_s_at 0.04 1.5
THEM4 cg03147210a TSS200 0.05 −0.52 229253_at 0.03 1.7
TFAMc cg03859893b TSS200 0.05 −1.02 238443_at 0.05 2.5
  1. Data are presented as mean ± SD
  2. Methylation Difference:  % Methylation (Ob)- % Methylation (L); values for  % methylation of groups are located in Additional file 4: Table S4. Significant probes from global DNA methylation analysis and global gene expression analysis were overlaid for matching genes; Probeset ID represents a single gene that may contain multiple methylation (CpG) sites. IPA Canonical Pathway tool identified PI3K/AKT Signaling as significantly overrepresented in our significant gene list
  3. aInfinium I probe design
  4. bInfinium II probe design
  5. cIndicates genes validated via qPCR. Gene names are located in Additional file 4: Table S4