Comparison of visceral adipose tissue DNA methylation and gene expression profiles in female adolescents with obesity

Table 1 Participant characteristics

Subjects	N	Age (year)	Height (cm)	Weight (kg)^a	BMI^a
Gene expression cohort
Lean	15	15 ± 2	161 ± 6	56.3 ± 11.1	21.6 ± 2.7
African American	5	16 ± 3	162 ± 8	60.3 ± 14.2	22.4 ± 3.7
Caucasian	5	16 ± 1	162 ± 7	55.6 ± 9.3	21.2 ± 2.0
Hispanic	5	13 ± 2	158 ± 5	53.3 ± 9.3	21.1 ± 2.0
Obese	15	17 ± 2	162 ± 8	124.4 ± 29	47.0 ± 9.7
African American	5	16 ± 2	165 ± 7	140.2 ± 20.6	51.7 ± 9.8
Caucasian	5	16 ± 2	163 ± 10	111.5 ± 37.7	41.5 ± 9.2
Hispanic	5	13 ± 2	158 ± 8	121.3 ± 23,6	47.8 ± 9.0
DNA methylation cohort
Lean	10	15 ± 3	162 ± 7	57.5 ± 2.9	21.9 ± 3.0
African American	4	16 ± 3	160 ± 7	57.2 ± 14.7	21.8 ± 4.0
Caucasian	2	16 ± 1	166 ± 9	64.5 ± 12.2	22.9 ± 1.6
Hispanic	4	13 ± 1	159 ± 5	54.8 ± 10.1	21.4 ± 2.6
Obese	10	15 ± 2	159 ± 7	114.2 ± 28.5	44.8 ± 9.8
African American	4	17 ± 3	164 ± 7	148.8 ± 8.7	55.6 ± 5.3
Caucasian	4	16 ± 2	159 ± 5	95.4 ± 12.6	37.9 ± 5.0
Hispanic	2	16 ± 1	153 ± 9	98.2 ± 3.0	42.1 ± 6.1

Data are mean ± SD
Methylation cohort represents a subcohort of the gene expression cohort; no statistical significance for phenotype data between the gene expression and methylation cohorts was found
BMI body mass index = weight (kg)/height (m)²
^aSignificant difference (p < 0.05) between lean and obese groups

ISSN: 1758-5996