TY - JOUR AU - Bjorntorp, P. PY - 1991 DA - 1991// TI - Metabolic implications of body fat distribution JO - Diab Care VL - 14 UR - https://doi.org/10.2337/diacare.14.12.1132 DO - 10.2337/diacare.14.12.1132 ID - Bjorntorp1991 ER - TY - JOUR AU - Despres, J. P. AU - Lemieux, I. PY - 2006 DA - 2006// TI - Abdominal obesity and metabolic syndrome JO - Nature VL - 444 UR - https://doi.org/10.1038/nature05488 DO - 10.1038/nature05488 ID - Despres2006 ER - TY - JOUR AU - Wajchenberg, B. L. PY - 2000 DA - 2000// TI - Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome JO - Endocr Rev VL - 21 UR - https://doi.org/10.1210/edrv.21.6.0415 DO - 10.1210/edrv.21.6.0415 ID - Wajchenberg2000 ER - TY - JOUR AU - Bays, H. PY - 2014 DA - 2014// TI - Central obesity as a clinical marker of adiposopathy; increased visceral adiposity as a surrogate marker for global fat dysfunction JO - Curr Opin Endocrinol Diab Obes VL - 21 UR - https://doi.org/10.1097/MED.0000000000000093 DO - 10.1097/MED.0000000000000093 ID - Bays2014 ER - TY - JOUR AU - O’Rahilly, S. PY - 2009 DA - 2009// TI - Human genetics illuminates the paths to metabolic disease JO - Nature VL - 462 UR - https://doi.org/10.1038/nature08532 DO - 10.1038/nature08532 ID - O’Rahilly2009 ER - TY - JOUR AU - Lavebratt, C. AU - Almgren, M. AU - Ekstrom, T. J. PY - 2012 DA - 2012// TI - Epigenetic regulation in obesity JO - Int J Obes (Lond) VL - 36 UR - https://doi.org/10.1038/ijo.2011.178 DO - 10.1038/ijo.2011.178 ID - Lavebratt2012 ER - TY - JOUR AU - Barres, R. AU - Zierath, J. R. PY - 2011 DA - 2011// TI - DNA methylation in metabolic disorders JO - Am J Clin Nutr VL - 93 UR - https://doi.org/10.3945/ajcn.110.001933 DO - 10.3945/ajcn.110.001933 ID - Barres2011 ER - TY - JOUR AU - Barajas-Olmos, F. AU - Centeno-Cruz, F. AU - Zerrweck, C. AU - Imaz-Rosshandler, I. AU - Martinez-Hernandez, A. AU - Cordova, E. J. PY - 2018 DA - 2018// TI - Altered DNA methylation in liver and adipose tissues derived from individuals with obesity and type 2 diabetes JO - BMC Med Genet VL - 19 UR - https://doi.org/10.1186/s12881-018-0542-8 DO - 10.1186/s12881-018-0542-8 ID - Barajas-Olmos2018 ER - TY - JOUR AU - Nilsson, E. AU - Jansson, P. A. AU - Perfilyev, A. AU - Volkov, P. AU - Pedersen, M. AU - Svensson, M. K. PY - 2014 DA - 2014// TI - Altered DNA methylation and differential expression of genes influencing metabolism and inflammation in adipose tissue from subjects with type 2 diabetes JO - Diabetes VL - 63 UR - https://doi.org/10.2337/db13-1459 DO - 10.2337/db13-1459 ID - Nilsson2014 ER - TY - JOUR AU - Barres, R. AU - Kirchner, H. AU - Rasmussen, M. AU - Yan, J. AU - Kantor, F. R. AU - Krook, A. PY - 2013 DA - 2013// TI - Weight loss after gastric bypass surgery in human obesity remodels promoter methylation JO - Cell Rep VL - 3 UR - https://doi.org/10.1016/j.celrep.2013.03.018 DO - 10.1016/j.celrep.2013.03.018 ID - Barres2013 ER - TY - JOUR AU - Ronn, T. AU - Volkov, P. AU - Davegardh, C. AU - Dayeh, T. AU - Hall, E. AU - Olsson, A. H. PY - 2013 DA - 2013// TI - A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue JO - PLoS Genet VL - 9 UR - https://doi.org/10.1371/journal.pgen.1003572 DO - 10.1371/journal.pgen.1003572 ID - Ronn2013 ER - TY - JOUR AU - Keller, M. AU - Kralisch, S. AU - Rohde, K. AU - Schleinitz, D. AU - Dietrich, A. AU - Schon, M. R. PY - 2014 DA - 2014// TI - Global DNA methylation levels in human adipose tissue are related to fat distribution and glucose homeostasis JO - Diabetologia VL - 57 UR - https://doi.org/10.1007/s00125-014-3356-z DO - 10.1007/s00125-014-3356-z ID - Keller2014 ER - TY - JOUR AU - Guenard, F. AU - Tchernof, A. AU - Deshaies, Y. AU - Perusse, L. AU - Biron, S. AU - Lescelleur, O. PY - 2014 DA - 2014// TI - Differential methylation in visceral adipose tissue of obese men discordant for metabolic disturbances JO - Physiol Genomics VL - 46 UR - https://doi.org/10.1152/physiolgenomics.00160.2013 DO - 10.1152/physiolgenomics.00160.2013 ID - Guenard2014 ER - TY - JOUR AU - Keller, M. AU - Hopp, L. AU - Liu, X. AU - Wohland, T. AU - Rohde, K. AU - Cancello, R. PY - 2017 DA - 2017// TI - Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity JO - Mol Metab VL - 6 UR - https://doi.org/10.1016/j.molmet.2016.11.003 DO - 10.1016/j.molmet.2016.11.003 ID - Keller2017 ER - TY - JOUR AU - Kurylowicz, A. AU - Owczarz, M. AU - Polosak, J. AU - Jonas, M. I. AU - Lisik, W. AU - Jonas, M. PY - 2016 DA - 2016// TI - SIRT1 and SIRT7 expression in adipose tissues of obese and normal-weight individuals is regulated by microRNAs but not by methylation status JO - Int J Obes (Lond) VL - 40 UR - https://doi.org/10.1038/ijo.2016.131 DO - 10.1038/ijo.2016.131 ID - Kurylowicz2016 ER - TY - JOUR AU - Turcot, V. AU - Tchernof, A. AU - Deshaies, Y. AU - Perusse, L. AU - Belisle, A. AU - Marceau, S. PY - 2012 DA - 2012// TI - LINE-1 methylation in visceral adipose tissue of severely obese individuals is associated with metabolic syndrome status and related phenotypes JO - Clin Epigenetics VL - 4 UR - https://doi.org/10.1186/1868-7083-4-10 DO - 10.1186/1868-7083-4-10 ID - Turcot2012 ER - TY - JOUR AU - Benton, M. C. AU - Johnstone, A. AU - Eccles, D. AU - Harmon, B. AU - Hayes, M. T. AU - Lea, R. A. PY - 2015 DA - 2015// TI - An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss JO - Genome Biol VL - 16 UR - https://doi.org/10.1186/s13059-014-0569-x DO - 10.1186/s13059-014-0569-x ID - Benton2015 ER - TY - JOUR AU - Rzehak, P. AU - Covic, M. AU - Saffery, R. AU - Reischl, E. AU - Wahl, S. AU - Grote, V. PY - 2017 DA - 2017// TI - DNA-Methylation and body composition in preschool children: epigenome-wide-analysis in the European Childhood Obesity Project (CHOP)-Study JO - Sci Rep VL - 7 UR - https://doi.org/10.1038/s41598-017-13099-4 DO - 10.1038/s41598-017-13099-4 ID - Rzehak2017 ER - TY - JOUR AU - Huang, R. C. AU - Garratt, E. S. AU - Pan, H. AU - Wu, Y. AU - Davis, E. A. AU - Barton, S. J. PY - 2015 DA - 2015// TI - Genome-wide methylation analysis identifies differentially methylated CpG loci associated with severe obesity in childhood JO - Epigenetics VL - 10 UR - https://doi.org/10.1080/15592294.2015.1080411 DO - 10.1080/15592294.2015.1080411 ID - Huang2015 ER - TY - JOUR PY - 2004 DA - 2004// TI - Expression profiling—best practices for data generation and interpretation in clinical trials JO - Nat Rev Genet VL - 5 UR - https://doi.org/10.1038/nrg1297 DO - 10.1038/nrg1297 ID - ref20 ER - TY - JOUR AU - Du, P. AU - Zhang, X. AU - Huang, C. C. AU - Jafari, N. AU - Kibbe, W. A. AU - Hou, L. PY - 2010 DA - 2010// TI - Comparison of Beta-value and M-value methods for quantifying methylation levels by microarray analysis JO - BMC Bioinform VL - 11 UR - https://doi.org/10.1186/1471-2105-11-587 DO - 10.1186/1471-2105-11-587 ID - Du2010 ER - TY - STD TI - Team RC. R: A language and environment for statistical computing. 2013. ID - ref22 ER - TY - JOUR AU - Bibikova, M. AU - Barnes, B. AU - Tsan, C. AU - Ho, V. AU - Klotzle, B. AU - Le, J. M. PY - 2011 DA - 2011// TI - High density DNA methylation array with single CpG site resolution JO - Genomics VL - 98 UR - https://doi.org/10.1016/j.ygeno.2011.07.007 DO - 10.1016/j.ygeno.2011.07.007 ID - Bibikova2011 ER - TY - JOUR AU - Chen, Y. A. AU - Lemire, M. AU - Choufani, S. AU - Butcher, D. T. AU - Grafodatskaya, D. AU - Zanke, B. W. PY - 2013 DA - 2013// TI - Discovery of cross-reactive probes and polymorphic CpGs in the illumina infinium humanmethylation450 microarray JO - Epigenetics VL - 8 UR - https://doi.org/10.4161/epi.23470 DO - 10.4161/epi.23470 ID - Chen2013 ER - TY - JOUR AU - Mathieu, P. AU - Poirier, P. AU - Pibarot, P. AU - Lemieux, I. AU - Despres, J. P. PY - 2009 DA - 2009// TI - Visceral obesity: the link among inflammation, hypertension, and cardiovascular disease JO - Hypertension VL - 53 UR - https://doi.org/10.1161/HYPERTENSIONAHA.108.110320 DO - 10.1161/HYPERTENSIONAHA.108.110320 ID - Mathieu2009 ER - TY - JOUR AU - Castellano-Castillo, D. AU - Moreno-Indias, I. AU - Sanchez-Alcoholado, L. AU - Ramos-Molina, B. AU - Alcaide-Torres, J. AU - Morcillo, S. PY - 2019 DA - 2019// TI - Altered adipose tissue DNA methylation status in metabolic syndrome: relationships between global DNA methylation and specific Methylation at adipogenic, lipid metabolism and inflammatory candidate genes and metabolic variables JO - J Clin Med VL - 8 UR - https://doi.org/10.3390/jcm8010087 DO - 10.3390/jcm8010087 ID - Castellano-Castillo2019 ER - TY - JOUR AU - Appelman, Y. AU - Rijn, B. B. AU - Haaf, M. E. AU - Boersma, E. AU - Peters, S. A. PY - 2015 DA - 2015// TI - Sex differences in cardiovascular risk factors and disease prevention JO - Atherosclerosis VL - 241 UR - https://doi.org/10.1016/j.atherosclerosis.2015.01.027 DO - 10.1016/j.atherosclerosis.2015.01.027 ID - Appelman2015 ER - TY - JOUR AU - Young, M. T. AU - Phelan, M. J. AU - Nguyen, N. T. PY - 2016 DA - 2016// TI - A decade analysis of trends and outcomes of male vs female patients who underwent bariatric surgery JO - J Am Coll Surg VL - 222 UR - https://doi.org/10.1016/j.jamcollsurg.2015.11.033 DO - 10.1016/j.jamcollsurg.2015.11.033 ID - Young2016 ER - TY - JOUR AU - Lev Maor, G. AU - Yearim, A. AU - Ast, G. PY - 2015 DA - 2015// TI - The alternative role of DNA methylation in splicing regulation JO - Trends Genet VL - 31 UR - https://doi.org/10.1016/j.tig.2015.03.002 DO - 10.1016/j.tig.2015.03.002 ID - Lev Maor2015 ER - TY - JOUR AU - Crujeiras, A. B. AU - Diaz-Lagares, A. AU - Moreno-Navarrete, J. M. AU - Sandoval, J. AU - Hervas, D. AU - Gomez, A. PY - 2016 DA - 2016// TI - Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subjects JO - Transl Res VL - 178 ID - Crujeiras2016 ER - TY - JOUR AU - Kurylowicz, A. AU - Jonas, M. AU - Lisik, W. AU - Jonas, M. AU - Wicik, Z. A. AU - Wierzbicki, Z. PY - 2015 DA - 2015// TI - Obesity is associated with a decrease in expression but not with the hypermethylation of thermogenesis-related genes in adipose tissues JO - J Transl Med VL - 13 UR - https://doi.org/10.1186/s12967-015-0395-2 DO - 10.1186/s12967-015-0395-2 ID - Kurylowicz2015 ER - TY - JOUR AU - Cong, L. N. AU - Chen, H. AU - Li, Y. AU - Zhou, L. AU - McGibbon, M. A. AU - Taylor, S. I. PY - 1997 DA - 1997// TI - Physiological role of Akt in insulin-stimulated translocation of GLUT4 in transfected rat adipose cells JO - Mol Endocrinol VL - 11 UR - https://doi.org/10.1210/mend.11.13.0027 DO - 10.1210/mend.11.13.0027 ID - Cong1997 ER - TY - JOUR AU - Millward, T. A. AU - Zolnierowicz, S. AU - Hemmings, B. A. PY - 1999 DA - 1999// TI - Regulation of protein kinase cascades by protein phosphatase 2A JO - Trends Biochem Sci VL - 24 UR - https://doi.org/10.1016/S0968-0004(99)01375-4 DO - 10.1016/S0968-0004(99)01375-4 ID - Millward1999 ER - TY - JOUR AU - Jun, H. S. AU - Hwang, K. AU - Kim, Y. AU - Park, T. PY - 2008 DA - 2008// TI - High-fat diet alters PP2A, TC10, and CIP4 expression in visceral adipose tissue of rats JO - Obesity (Silver Spring) VL - 16 UR - https://doi.org/10.1038/oby.2008.220 DO - 10.1038/oby.2008.220 ID - Jun2008 ER - TY - JOUR AU - Varadkar, P. AU - Despres, D. AU - Kraman, M. AU - Lozier, J. AU - Phadke, A. AU - Nagaraju, K. PY - 2014 DA - 2014// TI - The protein phosphatase 2A B56gamma regulatory subunit is required for heart development JO - Dev Dyn VL - 243 UR - https://doi.org/10.1002/dvdy.24111 DO - 10.1002/dvdy.24111 ID - Varadkar2014 ER - TY - JOUR AU - Cheng, Y. S. AU - Seibert, O. AU - Kloting, N. AU - Dietrich, A. AU - Strassburger, K. AU - Fernandez-Veledo, S. PY - 2015 DA - 2015// TI - PPP2R5C couples hepatic glucose and lipid homeostasis JO - PLoS Genet VL - 11 UR - https://doi.org/10.1371/journal.pgen.1005561 DO - 10.1371/journal.pgen.1005561 ID - Cheng2015 ER - TY - JOUR AU - Ortega-Molina, A. AU - Efeyan, A. AU - Lopez-Guadamillas, E. AU - Munoz-Martin, M. AU - Gomez-Lopez, G. AU - Canamero, M. PY - 2012 DA - 2012// TI - Pten positively regulates brown adipose function, energy expenditure, and longevity JO - Cell Metab VL - 15 UR - https://doi.org/10.1016/j.cmet.2012.02.001 DO - 10.1016/j.cmet.2012.02.001 ID - Ortega-Molina2012 ER - TY - JOUR AU - Kurlawalla-Martinez, C. AU - Stiles, B. AU - Wang, Y. AU - Devaskar, S. U. AU - Kahn, B. B. AU - Wu, H. PY - 2005 DA - 2005// TI - Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue JO - Mol Cell Biol VL - 25 UR - https://doi.org/10.1128/MCB.25.6.2498-2510.2005 DO - 10.1128/MCB.25.6.2498-2510.2005 ID - Kurlawalla-Martinez2005 ER - TY - JOUR AU - Pal, A. AU - Barber, T. M. AU - Bunt, M. AU - Rudge, S. A. AU - Zhang, Q. AU - Lachlan, K. L. PY - 2012 DA - 2012// TI - PTEN mutations as a cause of constitutive insulin sensitivity and obesity JO - N Engl J Med VL - 367 UR - https://doi.org/10.1056/NEJMoa1113966 DO - 10.1056/NEJMoa1113966 ID - Pal2012 ER - TY - JOUR AU - Ballak, D. B. AU - Essen, P. AU - Diepen, J. A. AU - Jansen, H. AU - Hijmans, A. AU - Matsuguchi, T. PY - 2014 DA - 2014// TI - MAP3K8 (TPL2/COT) affects obesity-induced adipose tissue inflammation without systemic effects in humans and in mice JO - PLoS ONE VL - 9 UR - https://doi.org/10.1371/journal.pone.0089615 DO - 10.1371/journal.pone.0089615 ID - Ballak2014 ER - TY - JOUR AU - Jager, J. AU - Gremeaux, T. AU - Gonzalez, T. AU - Bonnafous, S. AU - Debard, C. AU - Laville, M. PY - 2010 DA - 2010// TI - Tpl2 kinase is upregulated in adipose tissue in obesity and may mediate interleukin-1beta and tumor necrosis factor-{alpha} effects on extracellular signal-regulated kinase activation and lipolysis JO - Diabetes VL - 59 UR - https://doi.org/10.2337/db09-0470 DO - 10.2337/db09-0470 ID - Jager2010 ER - TY - JOUR AU - Zhou, Q. AU - Leeman, S. E. AU - Amar, S. PY - 2011 DA - 2011// TI - Signaling mechanisms in the restoration of impaired immune function due to diet-induced obesity JO - Proc Natl Acad Sci U S A VL - 108 UR - https://doi.org/10.1073/pnas.1019270108 DO - 10.1073/pnas.1019270108 ID - Zhou2011 ER - TY - JOUR AU - Park, J. AU - Li, Y. AU - Kim, S. H. AU - Yang, K. J. AU - Kong, G. AU - Shrestha, R. PY - 2014 DA - 2014// TI - New players in high fat diet-induced obesity: lETM1 and CTMP JO - Metabolism VL - 63 UR - https://doi.org/10.1016/j.metabol.2013.10.012 DO - 10.1016/j.metabol.2013.10.012 ID - Park2014 ER - TY - JOUR AU - Vernochet, C. AU - Mourier, A. AU - Bezy, O. AU - Macotela, Y. AU - Boucher, J. AU - Rardin, M. J. PY - 2012 DA - 2012// TI - Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance JO - Cell Metab VL - 16 UR - https://doi.org/10.1016/j.cmet.2012.10.016 DO - 10.1016/j.cmet.2012.10.016 ID - Vernochet2012 ER - TY - JOUR AU - Vernochet, C. AU - Damilano, F. AU - Mourier, A. AU - Bezy, O. AU - Mori, M. A. AU - Smyth, G. PY - 2014 DA - 2014// TI - Adipose tissue mitochondrial dysfunction triggers a lipodystrophic syndrome with insulin resistance, hepatosteatosis, and cardiovascular complications JO - FASEB J. VL - 28 UR - https://doi.org/10.1096/fj.14-253971 DO - 10.1096/fj.14-253971 ID - Vernochet2014 ER - TY - JOUR AU - Rong, J. X. AU - Qiu, Y. AU - Hansen, M. K. AU - Zhu, L. AU - Zhang, V. AU - Xie, M. PY - 2007 DA - 2007// TI - Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone JO - Diabetes VL - 56 UR - https://doi.org/10.2337/db06-1135 DO - 10.2337/db06-1135 ID - Rong2007 ER - TY - JOUR AU - Wilson-Fritch, L. AU - Nicoloro, S. AU - Chouinard, M. AU - Lazar, M. A. AU - Chui, P. C. AU - Leszyk, J. PY - 2004 DA - 2004// TI - Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone JO - J Clin Invest VL - 114 UR - https://doi.org/10.1172/JCI21752 DO - 10.1172/JCI21752 ID - Wilson-Fritch2004 ER - TY - JOUR AU - Mercken, E. M. AU - Crosby, S. D. AU - Lamming, D. W. AU - JeBailey, L. AU - Krzysik-Walker, S. AU - Villareal, D. T. PY - 2013 DA - 2013// TI - Calorie restriction in humans inhibits the PI3K/AKT pathway and induces a younger transcription profile JO - Aging Cell VL - 12 UR - https://doi.org/10.1111/acel.12088 DO - 10.1111/acel.12088 ID - Mercken2013 ER - TY - JOUR AU - Garaulet, M. AU - Viguerie, N. AU - Porubsky, S. AU - Klimcakova, E. AU - Clement, K. AU - Langin, D. PY - 2004 DA - 2004// TI - Adiponectin gene expression and plasma values in obese women during very-low-calorie diet. Relationship with cardiovascular risk factors and insulin resistance JO - J Clin Endocrinol Metab VL - 89 UR - https://doi.org/10.1210/jc.2003-031495 DO - 10.1210/jc.2003-031495 ID - Garaulet2004 ER - TY - JOUR AU - Viguerie, N. AU - Vidal, H. AU - Arner, P. AU - Holst, C. AU - Verdich, C. AU - Avizou, S. PY - 2005 DA - 2005// TI - Adipose tissue gene expression in obese subjects during low-fat and high-fat hypocaloric diets JO - Diabetologia VL - 48 UR - https://doi.org/10.1007/s00125-004-1618-x DO - 10.1007/s00125-004-1618-x ID - Viguerie2005 ER -