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Table 3 GMDR analysis for the best interaction combination models

From: Interaction between ELMO1 gene polymorphisms and environment factors on susceptibility to diabetic nephropathy in Chinese Han population

Locus no.

Best combination

Cross-validation consistency

Testing balanced accuracy

p-values*

Gene–hypertension interactionsa

 2

1, hypertension

8/10

0.598

0.6241

 3

1, 3, hypertension

6/10

0.562

0.377

 4

1, 2, 3, hypertension

5/10

0.545

0.857

 5

1, 2, 3, 4, hypertension

7/10

0.521

0.377

Gene–alcohol drinking interactionsb

 2

1, alcohol drinking

10/10

0.621

0.0107

 3

1, 3, alcohol drinking

8/10

0.599

0.1719

 4

1, 2, 4, alcohol drinking

7/10

0.558

0.3770

 5

1, 2, 3, 4, alcohol drinking

8/10

0.476

0.5316

  1. SNPs named with 1–4 were rs741301, rs1345365, rs10255208 and rs7782979 respectively
  2. aAdjusted for age, gender, BMI, smoking and alcohol drinking
  3. bAdjusted for age, gender, BMI, hypertension and smoking