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Table 2 Association analysis for four SNPs within ELMO1 gene and DN susceptibility

From: Interaction between ELMO1 gene polymorphisms and environment factors on susceptibility to diabetic nephropathy in Chinese Han population

SNPsGenotypes or allelesFrequencies N (%)OR (95% CI)ap-valuesp-values for HWE test in controls
Normal controls (n = 665)DN patients (n = 660)
rs741301AA genotype430 (64.7)325 (49.2)1.00 (ref) 0.148
 AG genotype202 (30.4)265 (40.2)1.68 (1.15–2.23)< 0.001 
 GG genotype33 (5.0)70 (10.6)2.04 (1.29–2.82)< 0.001 
 A allele1062 (79.8)915 (69.3)1.00 (ref)  
 G allele268 (20.2)405 (30.7)1.75 (1.19–2.28)< 0.001 
rs1345365AA genotype415 (62.4)382 (57.9)1.00 (ref) 0.228
 AG genotype214 (32.2)235 (35.6)1.20 (0.80–1.81)0.462 
 GG genotype36 (5.4)43 (6.5)1.51 (0.69–2.32)0.613 
 A allele1044 (78.5)999 (75.7)1.00 (ref)  
 G allele286 (21.5)321 (24.3)1.24 (0.77–1.95)0.529 
rs10255208AA genotype426 (64.1)351 (53.2)1.00 (ref) 0.294
 AG genotype207 (31.1)245 (37.1)1.28 (0.88–1.77)0.425 
 GG genotype32 (4.8)64 (9.7)1.90 (1.30–2.59)< 0.001 
 A allele1059 (79.6)947 (71.7)1.00 (ref)  
 G allele271 (20.4)373 (28.3)1.41 (1.06–1.92)0.021 
rs7782979CC genotype409 (61.5)376 (57.0)1.00 (ref) 0.592
 CA genotype228 (34.3)242 (36.7)1.20 (0.84–1.72)0.487 
 AA genotype28 (4.2)42 (6.4)1.29 (0.76–1.97)0.641 
 C allele1046 (78.6)994 (75.3)1.00 (ref)  
 A allele284 (21.4)326 (24.7)1.23 (0.82–1.76)0.583 
  1. aAdjusted for age, gender, BMI, hypertension, smoking and alcohol drinking