Table 2 Association analysis for four SNPs within ELMO1 gene and DN susceptibility
SNPs | Genotypes or alleles | Frequencies N (%) | OR (95% CI)a | p-values | p-values for HWE test in controls | |
|---|---|---|---|---|---|---|
Normal controls (n = 665) | DN patients (n = 660) | |||||
rs741301 | AA genotype | 430 (64.7) | 325 (49.2) | 1.00 (ref) | 0.148 | |
AG genotype | 202 (30.4) | 265 (40.2) | 1.68 (1.15–2.23) | < 0.001 | ||
GG genotype | 33 (5.0) | 70 (10.6) | 2.04 (1.29–2.82) | < 0.001 | ||
A allele | 1062 (79.8) | 915 (69.3) | 1.00 (ref) | |||
G allele | 268 (20.2) | 405 (30.7) | 1.75 (1.19–2.28) | < 0.001 | ||
rs1345365 | AA genotype | 415 (62.4) | 382 (57.9) | 1.00 (ref) | 0.228 | |
AG genotype | 214 (32.2) | 235 (35.6) | 1.20 (0.80–1.81) | 0.462 | ||
GG genotype | 36 (5.4) | 43 (6.5) | 1.51 (0.69–2.32) | 0.613 | ||
A allele | 1044 (78.5) | 999 (75.7) | 1.00 (ref) | |||
G allele | 286 (21.5) | 321 (24.3) | 1.24 (0.77–1.95) | 0.529 | ||
rs10255208 | AA genotype | 426 (64.1) | 351 (53.2) | 1.00 (ref) | 0.294 | |
AG genotype | 207 (31.1) | 245 (37.1) | 1.28 (0.88–1.77) | 0.425 | ||
GG genotype | 32 (4.8) | 64 (9.7) | 1.90 (1.30–2.59) | < 0.001 | ||
A allele | 1059 (79.6) | 947 (71.7) | 1.00 (ref) | |||
G allele | 271 (20.4) | 373 (28.3) | 1.41 (1.06–1.92) | 0.021 | ||
rs7782979 | CC genotype | 409 (61.5) | 376 (57.0) | 1.00 (ref) | 0.592 | |
CA genotype | 228 (34.3) | 242 (36.7) | 1.20 (0.84–1.72) | 0.487 | ||
AA genotype | 28 (4.2) | 42 (6.4) | 1.29 (0.76–1.97) | 0.641 | ||
C allele | 1046 (78.6) | 994 (75.3) | 1.00 (ref) | |||
A allele | 284 (21.4) | 326 (24.7) | 1.23 (0.82–1.76) | 0.583 | ||