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Table 3 Genes modified by metformin treatment

From: Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats

Gene symbolV vs. ZLMet vs. VGene description
Genes corrected by metformin
Igfbp1g5.2519.28Insulin-like growth factor-binding protein 1
Ccrn4lb4.0310.24CCR4 carbon catabolite repression 4-like B
Stac312.779.35SH3- and cysteine-rich domain 3
Sdsg4.838.56Serine dehydratase
Pnpla313.038.23Patatin-like phospholipase domain containing 3
Lcn219.507.81Lipocalin 2
Btg22.096.96B-cell translocation gene 2, anti-proliferative
Coq10b2.345.41Coenzyme Q10 homolog B
A2m6.915.40Alpha-2-macroglobulin
Cyp7a1bcs2.815.01Cytochrome P450, family 7, subfamily a, polypeptide 1
Cdh178.394.66Cadherin 17
LOC313220b5.074.21Similar to bile acid coenzyme A
Sqles2.254.13Squalene epoxidase
Me12.554.12Malic enzyme 1, NADP(+) dependent, cytosolic
G6pdxg3.013.81Glucose-6-phosphate dehydrogenase X-linked
Rhbdd22.513.77Rhomboid domain containing 2
Cml44.493.48Camello-like 4
Car34.713.30Carbonic anhydrase 3
Inmt8.283.28Indolethylamine N-methyltransferase
Nrep2.783.08Neuronal regeneration-related protein
Hmgcs1cs2.003.073-Hydroxy-3-methylglutaryl-coenzyme A synthase 1
Mup53.183.05Major urinary protein 5
RGD15657092.383.03Similar to ovostatin-2
RGD15620603.432.92Similar to short-chain dehydrogenase reductase 9
Ddhd12.842.89DDHD domain containing 1
Por2.192.78P450 (cytochrome) oxidoreductase
Cyp3a9s3.552.69Cytochrome P450, family 3, subfamily a, polypeptide 9
Slc1a22.642.46Solute carrier family 1, member 2
Fmo13.912.45Flavin-containing monooxygenase 1
Dhrs73.592.39Dehydrogenase/reductase (SDR family) member 7
Aox33.222.27Aldehyde oxidase 3
LOC3602284.292.25WDNM1 homolog
Rdh22.992.17Retinol dehydrogenase 2
Hao22.732.13Hydroxyacid oxidase 2 (long chain)
Nox43.572.07NADPH oxidase 4
Obp3/Mup42.162.00Alpha-2u globulin PGCL4/major urinary protein 4
Genes uncorrected by metformin
Dbp2.351.50D site albumin promoter-binding protein
Acsm3f2.721.82Acyl-CoA synthetase medium-chain family member3
Chka2.061.80Choline kinase alpha
Scd1f2.021.47Stearoyl-coenzyme A desaturase 1
Ugp2g2.161.23UDP-glucose pyrophosphorylase 2
Inhba2.251.56Inhibin beta-A
Prtfdc12.171.61Phosphoribosyl transferase domain containing 1
Es222.001.30Esterase 22
Ces32.661.52Carboxylesterase 3
Esm12.201.74Endothelial cell-specific molecule 1
Prlr2.531.63Prolactin receptor
Fabp7f2.141.63Fatty acid-binding protein 7, brain
Slc16a102.101.77Solute carrier family 16, member 10
Upp23.331.95Uridine phosphorylase 2
Insig1cs3.061.54Insulin-induced gene 1
RGD15616192.831.79Similar to Camello-like 2
Slco1a42.201.23Solute carrier organic anion transporter family, member 1a4
Adfpf2.061.25Adipose differentiation-related protein
Ces32.501.62Carboxylesterase 3
  1. bBile acid metabolisms, c cholesterol metabolisms, f fatty acid metabolisms, g glucose metabolisms, s sterol metabolisms