Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats

Sui, Yi; Kong, Xianhe; Fan, Rongrong; Ye, Yanbin; Mai, Haiyan; Zhuo, Shuyu; Lu, Wei; Ruan, Peishan; Fang, Shi; Yang, Tao

doi:10.1186/s13098-019-0491-1

Diabetology & Metabolic Syndrome

Table 3 Genes modified by metformin treatment

From: Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats

Gene symbol	V vs. ZL		Met vs. V		Gene description
Genes corrected by metformin
Igfbp1^g	5.25	↓	19.28	↑	Insulin-like growth factor-binding protein 1
Ccrn4lb	4.03	↓	10.24	↑	CCR4 carbon catabolite repression 4-like B
Stac3	12.77	↓	9.35	↑	SH3- and cysteine-rich domain 3
Sds^g	4.83	↓	8.56	↑	Serine dehydratase
Pnpla3	13.03	↑	8.23	↓	Patatin-like phospholipase domain containing 3
Lcn2	19.50	↑	7.81	↓	Lipocalin 2
Btg2	2.09	↓	6.96	↑	B-cell translocation gene 2, anti-proliferative
Coq10b	2.34	↓	5.41	↑	Coenzyme Q10 homolog B
A2m	6.91	↑	5.40	↓	Alpha-2-macroglobulin
Cyp7a1^bcs	2.81	↓	5.01	↑	Cytochrome P450, family 7, subfamily a, polypeptide 1
Cdh17	8.39	↓	4.66	↑	Cadherin 17
LOC313220^b	5.07	↓	4.21	↑	Similar to bile acid coenzyme A
Sqle^s	2.25	↑	4.13	↓	Squalene epoxidase
Me1	2.55	↑	4.12	↓	Malic enzyme 1, NADP(+) dependent, cytosolic
G6pdx^g	3.01	↑	3.81	↓	Glucose-6-phosphate dehydrogenase X-linked
Rhbdd2	2.51	↓	3.77	↑	Rhomboid domain containing 2
Cml4	4.49	↓	3.48	↑	Camello-like 4
Car3	4.71	↓	3.30	↑	Carbonic anhydrase 3
Inmt	8.28	↓	3.28	↑	Indolethylamine N-methyltransferase
Nrep	2.78	↓	3.08	↑	Neuronal regeneration-related protein
Hmgcs1^cs	2.00	↑	3.07	↓	3-Hydroxy-3-methylglutaryl-coenzyme A synthase 1
Mup5	3.18	↓	3.05	↑	Major urinary protein 5
RGD1565709	2.38	↓	3.03	↑	Similar to ovostatin-2
RGD1562060	3.43	↑	2.92	↓	Similar to short-chain dehydrogenase reductase 9
Ddhd1	2.84	↑	2.89	↓	DDHD domain containing 1
Por	2.19	↓	2.78	↑	P450 (cytochrome) oxidoreductase
Cyp3a9^s	3.55	↓	2.69	↑	Cytochrome P450, family 3, subfamily a, polypeptide 9
Slc1a2	2.64	↓	2.46	↑	Solute carrier family 1, member 2
Fmo1	3.91	↓	2.45	↑	Flavin-containing monooxygenase 1
Dhrs7	3.59	↓	2.39	↑	Dehydrogenase/reductase (SDR family) member 7
Aox3	3.22	↓	2.27	↑	Aldehyde oxidase 3
LOC360228	4.29	↑	2.25	↓	WDNM1 homolog
Rdh2	2.99	↓	2.17	↑	Retinol dehydrogenase 2
Hao2	2.73	↓	2.13	↑	Hydroxyacid oxidase 2 (long chain)
Nox4	3.57	↓	2.07	↑	NADPH oxidase 4
Obp3/Mup4	2.16	↓	2.00	↑	Alpha-2u globulin PGCL4/major urinary protein 4
Genes uncorrected by metformin
Dbp	2.35	↓	1.50	↑	D site albumin promoter-binding protein
Acsm3^f	2.72	↓	1.82	↑	Acyl-CoA synthetase medium-chain family member3
Chka	2.06	↑	1.80	↓	Choline kinase alpha
Scd1^f	2.02	↑	1.47	↓	Stearoyl-coenzyme A desaturase 1
Ugp2^g	2.16	↓	1.23	↑	UDP-glucose pyrophosphorylase 2
Inhba	2.25	↑	1.56	↓	Inhibin beta-A
Prtfdc1	2.17	↓	1.61	↑	Phosphoribosyl transferase domain containing 1
Es22	2.00	↓	1.30	↑	Esterase 22
Ces3	2.66	↓	1.52	↑	Carboxylesterase 3
Esm1	2.20	↑	1.74	↓	Endothelial cell-specific molecule 1
Prlr	2.53	↑	1.63	↓	Prolactin receptor
Fabp7^f	2.14	↓	1.63	↑	Fatty acid-binding protein 7, brain
Slc16a10	2.10	↓	1.77	↑	Solute carrier family 16, member 10
Upp2	3.33	↓	1.95	↑	Uridine phosphorylase 2
Insig1^cs	3.06	↑	1.54	↓	Insulin-induced gene 1
RGD1561619	2.83	↓	1.79	↑	Similar to Camello-like 2
Slco1a4	2.20	↓	1.23	↑	Solute carrier organic anion transporter family, member 1a4
Adfp^f	2.06	↑	1.25	↓	Adipose differentiation-related protein
Ces3	2.50	↓	1.62	↑	Carboxylesterase 3

^bBile acid metabolisms, ^c cholesterol metabolisms, ^f fatty acid metabolisms, ^g glucose metabolisms, ^s sterol metabolisms

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ISSN: 1758-5996

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