Long-term treatment with metformin in the prevention of fatty liver in Zucker diabetic fatty rats

Table 2 Metabolic characters of rats after 6-month treatment

	Zucker lean, n = 6	ZDF + Met, n = 7	ZDF + V, n = 7
Body weight (g)	390 ± 12	491 ± 29^a	485 ± 49^b
2-h OGTT blood glucose (mmol/L)	7.9 ± 1.7	11.4 ± 2.3^ac	14.7 ± 2.3^b
Serum total cholesterol (mmol/L)	1.07 ± 0.07	4.9 ± 1.0^a	5.0 ± 0.6^b
Serum triglyceride (mmol/L)	0.32 ± 0.02	8.9 ± 3.3^a	8.7 ± 1.9^b
Serum total protein (g/L)	70.0 ± 1.7	70.6 ± 1.7	73.0 ± 2.3
Serum albumin (g/L)	20.7 ± 0.6	16.1 ± 2.0^a	15.7 ± 1.4^b
ALT (U/L)	79.3 ± 11.4	139.9 ± 25.9^a	155.7 ± 79.2^b
AST (U/L)	86.7 ± 6.1	120.6 ± 22.8^a	156.3 ± 61.0^b

Data are mean ± SD
OGTT oral glucose tolerance test, ALT alanine aminotransferase, AST aspartate transaminase
^a,bp < 0.05 versus Zucker lean, ^c p < 0.05 versus V

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