Skip to main content

Table 2 Univariate logistic regression analysis of DPP-4 inhibitors vs metformin as first-line outpatient AD therapy with patient characteristics and comorbidities

From: Treatment patterns of drug-naive patients with type 2 diabetes mellitus: a retrospective cohort study using a Japanese hospital database

Prescribed drug class

Treatment factors

OR

95% CI

Lower limit

Upper limit

DPP-4 inhibitors

Renal diseasea

4.20*

3.82

4.63

Coronary heart disease and strokea

2.22*

2.13

2.32

Patient total visitsa

1.34*

1.28

1.41

Male vs femaleb

1.10*

1.06

1.14

Age at the index date

1.06*

1.05

1.06

Metformin

Liver diseasea

0.96§

0.92

1.00

Diabetic nephropathya

0.96#

0.90

1.03

Diabetic neuropathya

0.94#

0.87

1.03

BMIa

0.90*

0.89

0.92

HbA1c level,  %a

0.83*

0.80

0.86

Diabetic retinopathya

0.74*

0.70

0.79

  1. An OR > 1 indicates DPP-4 inhibitors were prescribed over metformin with the independent variable, and vice versa
  2. AD antidiabetes drugs, BMI body mass index, CI confidence interval, DPP-4 dipeptidyl peptidase-4, HbA1c glycated hemoglobin, ns non significant, OR odds ratio
  3. * p < 0.0001, §p = 0.044, #p = ns
  4. aAssessed within the 180 days before the index date
  5. bFemale were the referent group for male vs female. Patient’s total visits > sample median total visits vs patient’s total visits ≤ sample median total visits