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Table 3 Interaction analyses between HSD11B1 rs45487298:delA>insA and H6PD rs6688832:G>A polymorphisms in T2DM patients

From: Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity: a cross-sectional study

  rs45487298:delA>insA–rs6688832:G>A interaction F/P* P
< 3 minor alleles
(n = 871)
≥ 3 minor alleles
(n = 45)
Age (years) 58.6 ± 10.5 54.9 ± 8.9 0.021
Males (%) 43.2 51.1 0.370
T2DM duration (years) 10 (1–51) 10 (1–46) 0.656
Systolic BP (mmHg)a 136.5 ± 22.1 128.8 ± 18.2 0.553/0.457
Diastolic BP (mmHg)a 84.3 ± 12.6 81.7 ± 7.9 0.048/0.826
Body mass index (kg/m2)b 29.3 ± 5.3 27.4 ± 4.9 7.856/0.005
Waist circumference (cm)b 98.7 ± 12.0 97.5 ± 13.5 0.526/0.469
HbA1c (%) 7.2 ± 2.1 7.3 ± 2.1   0.678
Total cholesterol (mg/dL)c 208.8 ± 46.4 204.9 ± 46.4 0.179/0.673
HDL cholesterol (mg/dL)c 46.4 ± 11.6 46.4 ± 11.6 3.112/0.079
LDL cholesterol (mg/dL)c 135.3 ± 46.4 131.5 ± 61.9 0.084/0.775
Triglycerides (mg/dL)c 150.6 (26.6–1470.4) 124 (53.1–806.0) 1.102/0.295
MetS (%) 75.9 68.9 0.398
  1. Data expressed as mean ± SD, median (range), or %
  2. BP blood pressure, MetS metabolic syndrome, T2DM type 2 diabetes mellitus, HbA1c glycated hemoglobin
  3. * F and P values obtained from the general linear model univariate analyses, after adjusting for: aage and gender, use of medication for hypertension, and BMI; bage and gender; cage, gender, use of hypolipidemic medications
  4. P values were computed by χ2 test or Student’s t-test as appropriate. Only P values lower than the Bonferroni threshold (0.0055) were considered statistically significant