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Table 3 Interaction analyses between HSD11B1 rs45487298:delA>insA and H6PD rs6688832:G>A polymorphisms in T2DM patients

From: Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity: a cross-sectional study

 

rs45487298:delA>insA–rs6688832:G>A interaction

F/P*

P†

< 3 minor alleles

(n = 871)

≥ 3 minor alleles

(n = 45)

Age (years)

58.6 ± 10.5

54.9 ± 8.9

–

0.021

Males (%)

43.2

51.1

–

0.370

T2DM duration (years)

10 (1–51)

10 (1–46)

–

0.656

Systolic BP (mmHg)a

136.5 ± 22.1

128.8 ± 18.2

0.553/0.457

–

Diastolic BP (mmHg)a

84.3 ± 12.6

81.7 ± 7.9

0.048/0.826

–

Body mass index (kg/m2)b

29.3 ± 5.3

27.4 ± 4.9

7.856/0.005

–

Waist circumference (cm)b

98.7 ± 12.0

97.5 ± 13.5

0.526/0.469

–

HbA1c (%)

7.2 ± 2.1

7.3 ± 2.1

 

0.678

Total cholesterol (mg/dL)c

208.8 ± 46.4

204.9 ± 46.4

0.179/0.673

–

HDL cholesterol (mg/dL)c

46.4 ± 11.6

46.4 ± 11.6

3.112/0.079

–

LDL cholesterol (mg/dL)c

135.3 ± 46.4

131.5 ± 61.9

0.084/0.775

–

Triglycerides (mg/dL)c

150.6 (26.6–1470.4)

124 (53.1–806.0)

1.102/0.295

–

MetS (%)

75.9

68.9

–

0.398

  1. Data expressed as mean ± SD, median (range), or %
  2. BP blood pressure, MetS metabolic syndrome, T2DM type 2 diabetes mellitus, HbA1c glycated hemoglobin
  3. * F and P values obtained from the general linear model univariate analyses, after adjusting for: aage and gender, use of medication for hypertension, and BMI; bage and gender; cage, gender, use of hypolipidemic medications
  4. †P values were computed by χ2 test or Student’s t-test as appropriate. Only P values lower than the Bonferroni threshold (0.0055) were considered statistically significant