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Table 2 Clinical and laboratory characteristics of T2DM patients according to genotypes of the H6PD rs6688832:G>A polymorphism

From: Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity: a cross-sectional study

 

H6PD rs6688832:G>A polymorphism

F/P*

P†

G/G (n = 464)

G/A (n = 377)

A/A (n = 83)

Age (years)

59.0 ± 10.3

58.0 ± 10.6

56.7 ± 10.4

–

0.125

Males (%)

44.2

44.0

38.6

–

0.621

T2DM duration (years)

11 (1–47)

10 (1–51)

10 (1–48)

–

0.043

Systolic BP (mmHg)a

135.4 ± 21.3

136.9 ± 22.2

136.0 ± 24.0

1.401/0.242

–

Diastolic BP (mmHg)a

83.4 ± 11.2

85.0 ± 13.5

84.7 ± 13.0

2.656/0.071

–

Body mass index (kg/m2)b

29.1 ± 5.2

29.4 ± 5.4

28.6 ± 5.2

1.647/0.193

–

Waist circumference (cm)b

98.6 ± 12.6

98.5 ± 11.9

98.7 ± 10.7

0.003/0.997

–

HbA1c (%)

7.1 ± 2.1

7.2 ± 2.1

7.4 ± 2.3

 

0.196

Total cholesterol (mg/dL)c

208.8 ± 50.3

204.9 ± 42.5

220.4 ± 42.5

1.353/0.261

–

HDL cholesterol (mg/dL)c

46.4 ± 15.5

46.4 ± 11.6

46.4 ± 11.6

1.339/0.264

–

LDL cholesterol (mg/dL)a

131.5 ± 54.1

131.5 ± 42.5

3.7 ± 38.7

0.657/0.520

–

Triglycerides (mg/dL)c

150.7 (26.6–1470.3)

141.7 (0.3–1240.0)

150.7 (53.1–469.4)

0.414/0.661

–

MetS (%)

74.4

76.7

75.4

–

0.790

  1. Data expressed as mean ± SD, median (range), or %
  2. BP blood pressure, MetS metabolic syndrome, T2DM type 2 diabetes mellitus, HbA1c glycated hemoglobin
  3. * F and P values obtained from the general linear model univariate analyses, after adjusting for: aage and gender, use of medication for hypertension, and BMI; bage and gender; cage, gender, use of hypolipidemic medications
  4. †P values were computed by χ2 test or ANOVA as appropriate. Only P values lower than the Bonferroni threshold (0.0055) were considered statistically significant
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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