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Table 2 Clinical and laboratory characteristics of T2DM patients according to genotypes of the H6PD rs6688832:G>A polymorphism

From: Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity: a cross-sectional study

  H6PD rs6688832:G>A polymorphism F/P* P
G/G (n = 464) G/A (n = 377) A/A (n = 83)
Age (years) 59.0 ± 10.3 58.0 ± 10.6 56.7 ± 10.4 0.125
Males (%) 44.2 44.0 38.6 0.621
T2DM duration (years) 11 (1–47) 10 (1–51) 10 (1–48) 0.043
Systolic BP (mmHg)a 135.4 ± 21.3 136.9 ± 22.2 136.0 ± 24.0 1.401/0.242
Diastolic BP (mmHg)a 83.4 ± 11.2 85.0 ± 13.5 84.7 ± 13.0 2.656/0.071
Body mass index (kg/m2)b 29.1 ± 5.2 29.4 ± 5.4 28.6 ± 5.2 1.647/0.193
Waist circumference (cm)b 98.6 ± 12.6 98.5 ± 11.9 98.7 ± 10.7 0.003/0.997
HbA1c (%) 7.1 ± 2.1 7.2 ± 2.1 7.4 ± 2.3   0.196
Total cholesterol (mg/dL)c 208.8 ± 50.3 204.9 ± 42.5 220.4 ± 42.5 1.353/0.261
HDL cholesterol (mg/dL)c 46.4 ± 15.5 46.4 ± 11.6 46.4 ± 11.6 1.339/0.264
LDL cholesterol (mg/dL)a 131.5 ± 54.1 131.5 ± 42.5 3.7 ± 38.7 0.657/0.520
Triglycerides (mg/dL)c 150.7 (26.6–1470.3) 141.7 (0.3–1240.0) 150.7 (53.1–469.4) 0.414/0.661
MetS (%) 74.4 76.7 75.4 0.790
  1. Data expressed as mean ± SD, median (range), or %
  2. BP blood pressure, MetS metabolic syndrome, T2DM type 2 diabetes mellitus, HbA1c glycated hemoglobin
  3. * F and P values obtained from the general linear model univariate analyses, after adjusting for: aage and gender, use of medication for hypertension, and BMI; bage and gender; cage, gender, use of hypolipidemic medications
  4. P values were computed by χ2 test or ANOVA as appropriate. Only P values lower than the Bonferroni threshold (0.0055) were considered statistically significant