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Table 1 Clinical and laboratory characteristics of T2DM patients according to genotypes of the HSD11B1 rs45487298:delA>insA polymorphism

From: Interaction of HSD11B1 and H6PD polymorphisms in subjects with type 2 diabetes are protective factors against obesity: a cross-sectional study

  HSD11B1 rs45487298:delA>insA polymorphism F/P* P
DelA/DelA
(n = 654)
DelA/InsA
(n = 311)
InsA/InsA
(n = 33)
Age (years) 58.5 ± 10.6 58.2 ± 10.0 57.3 ± 8.9 0.642
Males (%) 42.8 43.4 54.5 0.415
T2DM duration (years) 10.0 (1–48) 10.0 (1–51) 12.5 (1–46) 0.330
Systolic BP (mmHg)a 137.7 ± 22.6 133.1 ± 20.2 131.0 ± 13.8 2.952/0.053
Diastolic BP (mmHg)a 84.7 ± 12.2 83.3 ± 12.8 83.0 ± 7.6 0.591/0.554
Body mass index (kg/m2)b 29.2 ± 5.0 29.3 ± 5.6 28.4 ± 4.9 0.250/0.778
Waist circumference (cm)b 98.7 ± 12.3 98.7 ± 11.6 100.8 ± 14.4 0.141/0.868
HbA1c (%) 7.2 ± 2.1 7.4 ± 2.1 7.3 ± 2.3   0.909
Total cholesterol (mg/dL)b 208.8 ± 46.4 208.8 ± 50.3 193.3 ± 54.1 0.682/0.384
HDL cholesterol (mg/dL)c 46.4 ± 11.6 50.3 ± 11.6 42.5 ± 19.3 2.488/0.116
LDL cholesterol (mg/dL)c 135.3 ± 50.3 131.5 ± 50.3 112.1 ± 23.2 1.889/0.155
Triglycerides (mg/dL)c 141.7 (26.6–1470.3) 150.6 (26.6–779.5) 230.3 (44.3–806.0) 0.280/0.756
MetS (%) 78.8 73.4 78.6 0.232
  1. Data expressed as mean ± SD, median (range), or %
  2. BP blood pressure, MetS metabolic syndrome, T2DM type 2 diabetes mellitus, HbA1c glycated hemoglobin
  3. * F and P values obtained from the general linear model univariate analyses, after adjusting for: aage and gender, use of medication for hypertension, and BMI; bage and gender; cage, gender and use of hypolipidemic medications
  4. P values were computed by χ2 test or ANOVA as appropriate. Only P values lower than the Bonferroni threshold (0.0055) were considered statistically significant