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Table 3 Comparison of early pregnancy factors for GDM in normal weight women (PPBMI < 25 kg/m2) with and without PCOS

From: Early pregnancy metabolic factors associated with gestational diabetes mellitus in normal-weight women with polycystic ovary syndrome: a two-phase cohort study

 

PCOS (n = 147)

Non-PCOS (n = 185)

p-value*

Gravidity, mean ± SD

1.52 ± 1.38

1.70 ± 1.56

0.08

Parity, mean ± SD

1.04 ± 1.01

1.06 ± 1.03

0.4

History of EPL, n (%)

33 (22.5)

33 (17.8)

0.3

IVF–ET, n (%)

16 (10.9)

5 (2.7)

0.002

Family history of DM, n (%)

24 (16.3)

23 (12.4)

0.3

Family history of hypertension, n (%)

33 (22.5)

28 (15.1)

0.09

SBP, mmHg, mean ± SD

110.6 ± 11.7

114.0 ± 11.4

0.006

DBP, mmHg, mean ± SD

69.4 ± 9.3

71.9 ± 9.0

0.01

FPG, mmol/L, mean ± SD

4.83 ± 0.53

4.74 ± 0.49

0.1

Fins, mIU/L, mean ± SD

10.77 ± 5.45

9.62 ± 4.89

0.06

LogHoMA−IR, mean ± SD

0.70 ± 0.55

0.57 ± 0.57

0.05

QUICKY, mean ± SD

0.34 ± 0.03

0.35 ± 0.03

0.05

Lipid profile

 TC, mmol/L, mean ± SD

4.50 ± 0.73

4.41 ± 0.76

0.3

 TG, mmol/L, mean ± SD

1.51 ± 0.84

1.30 ± 0.75

0.02

 HDL, mmol/L, mean ± SD

1.93 ± 1.60

1.98 ± 0.73

0.7

 LDL, mmol/L, mean ± SD

1.97 ± 0.50

2.13 ± 0.52

0.004

 ApoA1, mmol/L, mean ± SD

1.53 ± 0.37

1.47 ± 0.29

0.06

 ApoB, mmol/L, mean ± SD

0.69 ± 0.15

0.72 ± 0.15

0.06

 Lp (a), mg/L, mean ± SD

252.4 ± 296.3

286.5 ± 283.5

0.3

APN, μg/mL, mean ± SD

75.25 ± 43.59

72.61 ± 36.26

0.6

SHBG, nmol/L, mean ± SD

277.8 ± 110.2

330.5 ± 180.4

0.001

  1. Italic values are statistically significant at p < 0.05
  2. Family history of DM and hypertension means related history of first degree relatives
  3. GDM gestational diabetes, PPBMI pre-pregnancy body mass index, PCOS polycystic ovary syndrome, EPL early pregnancy loss, IVF–ET in vitro fertilization and embryo transfer, DM diabetes mellitus, SBP systolic blood pressure, DBP diastolic blood pressure, FPG fasting plasma glucose, Fins fasting insulin, HoMA-IR Homeostasis Model Assessment-insulin Resistance, QUICKI quantitative insulin sensitivity check index, TC total cholesterol, TG triglycerides, HDL high density lipoprotein-cholesterol, LDL low density lipoprotein-cholesterol, ApoA1 apolipoprotein A-I, ApoB apolipoprotein B, Lp (a) lipoprotein a, APN adiponectin, SHBG sex hormone-binding globulin
  4. * p-value was calculated by student t-test for numeric variables and by Chi square test for categorical variables