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Table 2 Characteristics of enrolled patients

From: Assessment of dapagliflozin effect on diabetic endothelial dysfunction of brachial artery (ADDENDA-BHS2 trial): rationale, design, and baseline characteristics of a randomized controlled trial

  Dapagliflozin Glibenclamide p-value
N 49 49  
Gender male, % 61 61 1.0
Age, years 57 ± 7 56 ± 7 0.4
T2DM duration, years 9 ± 6 10 ± 7 0.28
Hypertension, % 82 76 0.6
Prior smoking habit, % 45 38 0.5
Sedentarity, % 55 65 0.4
Heart rate, bpm 71 ± 11 73 ± 10 0.28
Office systolic blood pressure, mmHg 136 ± 13 138 ± 15 0.67
Office diastolic blood pressure, mmHg 81 ± 8 83 ± 9 0.4
24-h systolic blood pressure, mmHg 124 ± 10 127 ± 11 0.1
24-h diastolic blood pressure, mmHg 72 ± 20 72 ± 21 0.88
Body mass index, kg/m2 30 ± 4 30 ± 5 0.76
Waist circumference, cm 104 ± 11 103 ± 10 0.32
Body fat, % 36 ± 8 37 ± 7 0.78
Android fat mass, g 2957 ± 1017 3203 ± 997 0.23
Gynoid fat mass, g 4168 ± 1518 4355 ± 1768 0.58
Retinopathy, % 15 28 0.2
Foveal diameter area by OCT, μm 267 ± 20 265 ± 23 0.69
Distal polyneuropathy, % 43 41 0.8
Fasting blood glucose, mg/dl 174 ± 44 173 ± 58 0.99
HbA1c, % 7.8 ± 0.9 7.9 ± 0.9 0.74
Fasting insulin, mU/l 14 ± 7 16 ± 14 0.53
Total cholesterol, mg/dl 163 ± 39 164 ± 42 0.99
LDL-cholesterol, mg/dl 93 ± 30 96 ± 35 0.76
HDL-cholesterol, mg/dl 42 ± 11 41 ± 10 0.62
VLDL-cholesterol, mg/dl 29 ± 15 28 ± 10 0.77
Triglycerides, mg/dl 179 ± 112 174 ± 94 0.76
TSH, mIU/l 2.2 ± 1.2 2.2 ± 1.7 0.67
Glomerular filtration rate, ml/min 96 ± 20 92 ± 19 0.39
Urinary albumin/creatinine ratio, mg/g 0.2 ± 0.2 0.3 ± 0.3 0.29
High-sensitivity C-reactive protein, mg/dl 0.1 ± 0.4 0.3 ± 0.6 0.08
Aspartate aminotransferase, U/l 23 ± 10 21 ± 12 0.46
Alanine aminotransferase, U/l 30 ± 17 29 ± 20 0.81
Carotid IMT, mm 1.0 ± 0.2 1.0 ± 0.1 0.15
tho, % 49 49 0.5
Carotid plaque, % 80 74 0.6
Left atrium volume indexed, ml/m2 24 ± 6 23 ± 4 0.2
Left ventricle end-diastolic volume, ml 84 ± 32 85 ± 28 0.96
Left ventricle mass indexed, g/m2 86 ± 22 88 ± 24 0.67
Left ventricle ejection fraction, % 65 ± 8 62 ± 7 0.29
Global longitudinal strain of the left ventricle, % − 16 ± 8 − 15 ± 8 0.52
E/e′ ratio 7.9 ± 2.8 8.1 ± 2.2 0.99