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Table 2 Dose effect of chloroquine on blood pressure and other variables

From: Low dose chloroquine decreases insulin resistance in human metabolic syndrome but does not reduce carotid intima-media thickness

Variable

Placebo

80 mg/week

80 mg/day

250 mg/day

P value

SBP (mmHg)

121 ± 12

121 ± 10

123 ± 12

123 ± 12

0.5607

DBP (mmHg)

70 ± 7

71 ± 7

73 ± 8

73 ± 9

0.1107

MAP (mmHg)

87 ± 8

88 ± 7

89 ± 9

90 ± 9

0.1944

Overnight MAP dip

8.8 ± 4.2

9.5 ± 5.3

9.5 ± 8.8

9.6 ± 5.0

0.9878

Fasting glucose clamp

5.77 ± 0.53

5.83 ± 0.52

5.83 ± 0.53

5.44 ± 0.65

0.0010*

Fasting glucose OGTT

5.49 ± 0.57

5.77 ± 0.56

5.72 ± 0.62

5.66 ± 0.62

0.0805

OGTT AUC (mmol/L/h)

16.93 ± 3.05

17.65 ± 3.00

17.87 ± 3.22

17.26 ± 3.61

0.3585

Weight (kg)

104 ± 18

103 ± 18

104 ± 19

103 ± 19

0.6041

BMI

35.9 ± 4.3

35.9 ± 4.2

35.9 ± 4.5

35.5 ± 4.6

0.5964

A1c (%)

5.8 ± 0.4

ND

ND

5.8 ± 0.4

0.9493

Insulin (pmol/L)

153 ± 94

138 ± 62

166 ± 107

148 ± 80

0.4260

C peptide (nmol/L)

1.16 ± 0.44

1.20 ± 0.38

1.26 ± 0.44

1.25 ± 0.36

0.5473

Glucagon (pg/mL)

110 ± 41

101 ± 26

111 ± 54

102 ± 50

0.3646

Leptin (μg/L)

27.5 ± 11.6

27.2 ± 11.1

31.0 ± 16.4

27.2 ± 11.9

0.2134

NEFA (mmol/L)

0.56 ± 0.15

0.55 ± 0.10

0.58 ± 0.19

0.55 ± 0.16

0.8776

TNFα (pg/mL)

12.9 ± 1.8

13.0 ± 1.7

12.2 ± 1.9

12.4 ± 2.0

0.0890

Fibrinogen (μmol/L)

8.44 ± 1.32

8.38 ± 1.47

8.14 ± 1.09

7.94 ± 1.44

0.3563

IL-6 (pg/mL)

1.0 ± 1.6

1.4 ± 1.5

1.2 ± 1.6

0.96 ± 1.3

0.4282

Lp(a) (mg/dL)

22.9 ± 17.5

20.9 ± 16.0

22.5 ± 17.2

22.8 ± 18.1

0.1454

CRP (mg/L)

8.3 ± 10.8

7.9 ± 10.6

6.4 ± 7.2

7.5 ± 8.0

0.7455

Adiponectin (μg/mL)

21.6 ± 8.1

ND

ND

20.6 ± 5.6

0.3503

Iron (μmol/L)

12.3 ± 4.1

ND

ND

11.4 ± 5.5

0.5311

Iron Bind. Cap. (μmol/L)

64.9 ± 8.7

ND

ND

65.8 ± 10.0

0.6385

Transferrin (mg/dL)

300.3 ± 47.5

ND

ND

303.8 ± 48.5

0.6899

Transferrin Sat. (%)

19.1 ± 6.4

ND

ND

17.2 ± 6.9

0.3413

Ferritin (pmol/L)

170 ± 191

ND

ND

105 ± 88

0.0155*

  1. Data represent mean ± SD
  2. MAP mean arterial pressure, NEFA non-esterified fatty acids, ND not determined
  3. P values determined by repeated measures ANOVA except for A1c, adiponectin, and iron studies, where P value determined by paired t test
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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