Fig. 1
From: TCF7L2 regulates pancreatic β-cell function through PI3K/AKT signal pathway
Effects of glucose or insulin on gene transcription and insulin secretion. MIN6 cells were cultured with 5.6 mM, 11.2 mM and 25 mM glucose for 72 h or with 1 nM, 10 nM, 100 nM insulin for 6 h. a The expressions of TCF7L2, p85, Akt were determined by western blotting. b GSIS was performed on MIN6 cells in vitro and insulin concentrations in the supernatants were measured using ELISA (n = 3 samples per group, **p < 0.01 as indicated)