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Table 3 Odds ratios (ORs) and 95% confidence intervals (CIs) of prediabetes according to sex-specific quartiles of energy-adjusted NEAP and PRAL score

From: The dietary acid load is higher in subjects with prediabetes who are at greater risk of diabetes: a case–control study

Dietary acid load score

Q1

Q2

Q3

Q4

P for trend

No. of cases/control

Jul-38

Dec-37

25/38

103/37

 

NEAP, median (mEq/day)

23.3

29.1

34.8

42.7

 

Range

(8.0–26.72)

(26.66–32.49)

(32.28–38.31)

(38.41–89.0)

 

OR (95% CI)

 Model 1

1.00 (Ref)

1.76 (0.62–4.97)

3.53 (1.36–9.15)

15.22 (6.24–37.0)

< 0.001

 Model 2

1

1.71 (0.57–5.06)

2.27 (1.007–7.66)

14.48 (5.64–37.19)

< 0.001

 No. of cases/control

22/78

36/40

31/18

58/14

 

PRAL, median (mEq/day)

− 32.8

− 21.6

− 11.8

− 2.6

 

Range

(− 132.7, − 26.54)

(− 26.52, − 15.07)

(− 14.8, − 6.87)

(− 6.86, 32.9)

 

OR (95% CI)

 Model 1

1.00 (Ref)

3.65 (1.86–7.15)

9.24 (4.0–21.0)

29.83 (12.12–73.42)

< 0.001

 Model 2

1

3.88 (1.89–7.98)

9.14 (3.75–22.29)

25.61 (9.63–68.08)

< 0.001

  1. NEAP and PRAL were categorized into quartiles according to the distribution of the control group
  2. NEAP for overall subjects (Q1: < 30.05, Q2: 30.05–37.68, Q3: 37.69–47.24 and Q4: ≥ 47.25); PRAL for overall subjects (Q1 < − 19.15, Q2: − 19.15 to − 8.19, Q3: − 8.18 to 2.56 and Q4: ≥ 2.57)
  3. To test for a trend across quartiles, the median for each quartile category was used as a continuous variable
  4. Model 1: adjusted for age and sex
  5. Model 2: Model 1 further adjusted for BMI (kg/m2), education (years), physical activity (MET/h/week), and energy intake (Kcal/day)
  6. NEAP net endogenous acid production, PRAL potential renal acid load