|
Dietary acid load score
|
Q1
|
Q2
|
Q3
|
Q4
|
P for trend
|
|---|
|
No. of cases/control
|
Jul-38
|
Dec-37
|
25/38
|
103/37
| |
|
NEAP, median (mEq/day)
|
23.3
|
29.1
|
34.8
|
42.7
| |
|
Range
|
(8.0–26.72)
|
(26.66–32.49)
|
(32.28–38.31)
|
(38.41–89.0)
| |
|
OR (95% CI)
|
|
Model 1
|
1.00 (Ref)
|
1.76 (0.62–4.97)
|
3.53 (1.36–9.15)
|
15.22 (6.24–37.0)
|
< 0.001
|
|
Model 2
|
1
|
1.71 (0.57–5.06)
|
2.27 (1.007–7.66)
|
14.48 (5.64–37.19)
|
< 0.001
|
|
No. of cases/control
|
22/78
|
36/40
|
31/18
|
58/14
| |
|
PRAL, median (mEq/day)
|
− 32.8
|
− 21.6
|
− 11.8
|
− 2.6
| |
|
Range
|
(− 132.7, − 26.54)
|
(− 26.52, − 15.07)
|
(− 14.8, − 6.87)
|
(− 6.86, 32.9)
| |
|
OR (95% CI)
|
|
Model 1
|
1.00 (Ref)
|
3.65 (1.86–7.15)
|
9.24 (4.0–21.0)
|
29.83 (12.12–73.42)
|
< 0.001
|
|
Model 2
|
1
|
3.88 (1.89–7.98)
|
9.14 (3.75–22.29)
|
25.61 (9.63–68.08)
|
< 0.001
|
- NEAP and PRAL were categorized into quartiles according to the distribution of the control group
- NEAP for overall subjects (Q1: < 30.05, Q2: 30.05–37.68, Q3: 37.69–47.24 and Q4: ≥ 47.25); PRAL for overall subjects (Q1 < − 19.15, Q2: − 19.15 to − 8.19, Q3: − 8.18 to 2.56 and Q4: ≥ 2.57)
- To test for a trend across quartiles, the median for each quartile category was used as a continuous variable
- Model 1: adjusted for age and sex
- Model 2: Model 1 further adjusted for BMI (kg/m2), education (years), physical activity (MET/h/week), and energy intake (Kcal/day)
- NEAP net endogenous acid production, PRAL potential renal acid load
