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Table 3 Association between quartiles of adiponectin with metabolic syndrome risk score and its individual components, ERICA 2013–2014

From: Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents

Clinical outcomes Quartiles of adiponectin p for trends
First (n = 1092) Second (n = 1101) Third (n = 1112) Fourth (n = 1241)b
β (95% CI)
Model 1: adjusted for sex, age, skin color and socioeconomic status
 Waist circumference, cm Ref − 1.65 (− 2.98, − 0.31) − 3.04 (− 4.51, − 1.56) − 3.83 (− 5.20, − 2.46) < 0.001
 Systolic BP, mmHg Ref − 1.04 (− 2.29, 0.21) − 0.75 (− 2.05, 0.55) − 1.16 (− 2.70, 0.37) 0.220
 Diastolic BP, mmHg Ref − 0.07 (− 0.97, 0.84) − 0.10 (− 1.08, 0.88) − 0.31 (− 1.33, 0.71) 0.586
 Mean BP, mmHg Ref − 0.39 (− 1.33, 0.55) − 0.32 (− 1.35, 0.71) − 0.60 (− 1.72, 0.53) 0.381
 Triglycerides (log)a, mg/dl Ref 0.001 (− 0.05, 0.05) − 0.03 (− 0.07, 0.02) − 0.07 (− 0.12, − 0.02) 0.002
 HDL-c, mg/dl Ref − 0.43 (− 1.57, 0.71) 1.34 (0.15, 2.53) 3.05 (1.83, 4.26) < 0.001
 Fasting plasma glucose, mg/dl Ref 0.16 (− 0.65, 0.97) − 0.10 (− 0.84, 0.64) − 0.43 (− 1.46, 0.59) 0.308
 MetS-z, z-score Ref − 0.16 (− 0.45, 0.14) − 0.55 (− 0.86, − 0.24) − 0.98 (− 1.27, − 0.69) < 0.001
 MetS-z without waist circumference, z-score Ref 0.22 (− 0.25, 0.29) − 0.22 (− 0.49, 0.05) − 0.57 (− 0.82, − 0.32) < 0.001
Model 2: adjusted for variables in model 1 plus physical activity and skipping breakfast
 Waist circumference, cm Ref − 1.94 (− 3.36, − 0.53) − 3.28 (− 4.84, − 1.73) − 4.07 (− 5.56, − 2.58) < 0.001
 Systolic BP, mmHg Ref − 1.20 (− 2.47, 0.07) − 0.86 (− 2.22, 0.51) − 1.39 (− 3.02, 0.24) 0.165
 Diastolic BP, mmHg Ref − 0.17 (− 1.13, 0.79) − 0.09 (− 1.09, 0.91) − 0.48 (− 1.56, 0.60) 0.472
 Mean BP, mmHg Ref − 0.51 (− 1.49, 0.47) − 0.35 (− 1.41, 0.72) − 0.78 (− 1.98, 0.41) 0.293
 Triglycerides (log)a, mg/dl Ref − 0.01 (− 0.06, 0.04) − 0.04 (− 0.09, 0.01) − 0.08 (− 0.12, − 0.0− 3) 0.001
 HDL-c, mg/dl Ref − 0.23 (− 1.40, 0.95) 1.87 (0.59, 3.15) 3.02 (1.77, 4.27) < 0.001
 Fasting plasma glucose, mg/dl Ref − 0.05 (− 0.92, 0.82) − 0.44 (− 1.28, 0.39) − 0.62 (− 1.65, 0.41) 0.143
 MetS-z, z-score Ref − 0.29 (− 0.60, 0.02) − 0.71 (− 1.06, − 0.37) − 1.07 (− 1.38, − 0.75) < 0.001
 MetS-z without waist circumference, z-score Ref − 0.08 (− 0.36, 0.19) − 0.36 (− 0.65, − 0.07) − 0.63 (− 0.88, − 0.38) < 0.001
Model 3: adjusted for variables in models 2 plus body mass index
 Waist circumference, cm Ref − 0.42 (− 0.97, 0.14) − 0.27 (− 0.86, 0.31) − 0.81 (− 1.52, − 0.11) 0.030
 Systolic BP, mmHg Ref − 0.28 (− 0.58, 1.01) 0.96 (− 0.28, 2.20) 0.59 (− 0.78, 1.95) 0.218
 Diastolic BP, mmHg Ref 0.23 (− 0.72, 1.17) 0.68 (− 0.21, 1.57) 0.37 (− 0.62, 1.37) 0.373
 Mean BP, mmHg Ref 0.05 (− 0.92, 1.02) 0.78 (− 0.15, 1.71) 0.44 (− 0.61, 1.50) 0.275
 Triglycerides (log)a, mg/dl Ref 0.001 (− 0.50, 0.05) − 0.01 (− 0.06, 0.04) − 0.04 (− 0.09, 0.001) 0.049
 HDL-c, mg/dl Ref − 0.60 (− 1.79, 0.60) 1.11 (− 0.24, 2.46) 2.22 (0.98, 3.47) < 0.001
 Fasting plasma glucose, mg/dl Ref 0.03 (− 0.85, 0.91) − 0.28 (− 1.13, 0.58) − 0.43 (− 1.49, 0.63) 0.318
 MetS-z, z-scorec Ref 0.02 (− 0.25, 0.30) − 0.10 (− 0.38, 0.18) − 0.40 (− 0.66, − 0.14) 0.005
 MetS-z without waist circumference, z-scorec Ref 0.10 (− 0.20, 0.39) − 0.04 (− 0.33, 0.25) − 0.28 (− 0.53, − 0.03) 0.031
  1. BP, blood pressure; HDL-c, high density lipoprotein cholesterol; MetS-z, metabolic syndrome risk z-score
  2. aTriglycerides was log transformed
  3. bHighest values
  4. cMean of MetS-z: − 0.05 (SE 0.09); mean of MetS-z without waist circumference: − 0.04 (SE 0.06), p for heterogeneity < 0.001