Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents

Karen Sparrenberger; Mariana Sbaraini; Felipe Vogt Cureau; Gabriela Heiden Teló; Luciana Bahia; Beatriz D. Schaan

doi:10.1186/s13098-019-0435-9

Table 3 Association between quartiles of adiponectin with metabolic syndrome risk score and its individual components, ERICA 2013–2014

From: Higher adiponectin concentrations are associated with reduced metabolic syndrome risk independently of weight status in Brazilian adolescents

Clinical outcomes	Quartiles of adiponectin							p for trends
	First (n = 1092)	Second (n = 1101)		Third (n = 1112)		Fourth (n = 1241)^b
	β (95% CI)
Model 1: adjusted for sex, age, skin color and socioeconomic status
Waist circumference, cm	Ref	− 1.65	(− 2.98, − 0.31)	− 3.04	(− 4.51, − 1.56)	− 3.83	(− 5.20, − 2.46)	< 0.001
Systolic BP, mmHg	Ref	− 1.04	(− 2.29, 0.21)	− 0.75	(− 2.05, 0.55)	− 1.16	(− 2.70, 0.37)	0.220
Diastolic BP, mmHg	Ref	− 0.07	(− 0.97, 0.84)	− 0.10	(− 1.08, 0.88)	− 0.31	(− 1.33, 0.71)	0.586
Mean BP, mmHg	Ref	− 0.39	(− 1.33, 0.55)	− 0.32	(− 1.35, 0.71)	− 0.60	(− 1.72, 0.53)	0.381
Triglycerides (log)^a, mg/dl	Ref	0.001	(− 0.05, 0.05)	− 0.03	(− 0.07, 0.02)	− 0.07	(− 0.12, − 0.02)	0.002
HDL-c, mg/dl	Ref	− 0.43	(− 1.57, 0.71)	1.34	(0.15, 2.53)	3.05	(1.83, 4.26)	< 0.001
Fasting plasma glucose, mg/dl	Ref	0.16	(− 0.65, 0.97)	− 0.10	(− 0.84, 0.64)	− 0.43	(− 1.46, 0.59)	0.308
MetS-z, z-score	Ref	− 0.16	(− 0.45, 0.14)	− 0.55	(− 0.86, − 0.24)	− 0.98	(− 1.27, − 0.69)	< 0.001
MetS-z without waist circumference, z-score	Ref	0.22	(− 0.25, 0.29)	− 0.22	(− 0.49, 0.05)	− 0.57	(− 0.82, − 0.32)	< 0.001
Model 2: adjusted for variables in model 1 plus physical activity and skipping breakfast
Waist circumference, cm	Ref	− 1.94	(− 3.36, − 0.53)	− 3.28	(− 4.84, − 1.73)	− 4.07	(− 5.56, − 2.58)	< 0.001
Systolic BP, mmHg	Ref	− 1.20	(− 2.47, 0.07)	− 0.86	(− 2.22, 0.51)	− 1.39	(− 3.02, 0.24)	0.165
Diastolic BP, mmHg	Ref	− 0.17	(− 1.13, 0.79)	− 0.09	(− 1.09, 0.91)	− 0.48	(− 1.56, 0.60)	0.472
Mean BP, mmHg	Ref	− 0.51	(− 1.49, 0.47)	− 0.35	(− 1.41, 0.72)	− 0.78	(− 1.98, 0.41)	0.293
Triglycerides (log)^a, mg/dl	Ref	− 0.01	(− 0.06, 0.04)	− 0.04	(− 0.09, 0.01)	− 0.08	(− 0.12, − 0.0− 3)	0.001
HDL-c, mg/dl	Ref	− 0.23	(− 1.40, 0.95)	1.87	(0.59, 3.15)	3.02	(1.77, 4.27)	< 0.001
Fasting plasma glucose, mg/dl	Ref	− 0.05	(− 0.92, 0.82)	− 0.44	(− 1.28, 0.39)	− 0.62	(− 1.65, 0.41)	0.143
MetS-z, z-score	Ref	− 0.29	(− 0.60, 0.02)	− 0.71	(− 1.06, − 0.37)	− 1.07	(− 1.38, − 0.75)	< 0.001
MetS-z without waist circumference, z-score	Ref	− 0.08	(− 0.36, 0.19)	− 0.36	(− 0.65, − 0.07)	− 0.63	(− 0.88, − 0.38)	< 0.001
Model 3: adjusted for variables in models 2 plus body mass index
Waist circumference, cm	Ref	− 0.42	(− 0.97, 0.14)	− 0.27	(− 0.86, 0.31)	− 0.81	(− 1.52, − 0.11)	0.030
Systolic BP, mmHg	Ref	− 0.28	(− 0.58, 1.01)	0.96	(− 0.28, 2.20)	0.59	(− 0.78, 1.95)	0.218
Diastolic BP, mmHg	Ref	0.23	(− 0.72, 1.17)	0.68	(− 0.21, 1.57)	0.37	(− 0.62, 1.37)	0.373
Mean BP, mmHg	Ref	0.05	(− 0.92, 1.02)	0.78	(− 0.15, 1.71)	0.44	(− 0.61, 1.50)	0.275
Triglycerides (log)^a, mg/dl	Ref	0.001	(− 0.50, 0.05)	− 0.01	(− 0.06, 0.04)	− 0.04	(− 0.09, 0.001)	0.049
HDL-c, mg/dl	Ref	− 0.60	(− 1.79, 0.60)	1.11	(− 0.24, 2.46)	2.22	(0.98, 3.47)	< 0.001
Fasting plasma glucose, mg/dl	Ref	0.03	(− 0.85, 0.91)	− 0.28	(− 1.13, 0.58)	− 0.43	(− 1.49, 0.63)	0.318
MetS-z, z-score^c	Ref	0.02	(− 0.25, 0.30)	− 0.10	(− 0.38, 0.18)	− 0.40	(− 0.66, − 0.14)	0.005
MetS-z without waist circumference, z-score^c	Ref	0.10	(− 0.20, 0.39)	− 0.04	(− 0.33, 0.25)	− 0.28	(− 0.53, − 0.03)	0.031

BP, blood pressure; HDL-c, high density lipoprotein cholesterol; MetS-z, metabolic syndrome risk z-score
^aTriglycerides was log transformed
^bHighest values
^cMean of MetS-z: − 0.05 (SE 0.09); mean of MetS-z without waist circumference: − 0.04 (SE 0.06), p for heterogeneity < 0.001

Back to article page