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Table 2 Changes in inflammatory cytokines and oxidative stress after the intensive insulin therapy in T2DM patients (x ± s)

From: Effect of rosiglitazone on inflammatory cytokines and oxidative stress after intensive insulin therapy in patients with newly diagnosed type 2 diabetes

 

Rosiglitazone

Metformin

Rosiglitazone plus metformin

Insulin aspart 30

Baseline

48 weeks

Baseline

48 weeks

Baseline

48 weeks

Baseline

48 weeks

TNFα (pg/mL)

28.57 ± 10.37

22.12 ± 11.66*

30.24 ± 15.78

28.33 ± 12.34

27.91 ± 12.21

21.59 ± 9.82*

28.75 ± 13.84

27.87 ± 10.22

IL-6 (pg/mL)

8.13 ± 2.22

6.68 ± 3.69*

9.21 ± 3.12

8.79.45 ± 4.01

8.88 ± 3.91

5.13 ± 3.93*a

8.29 ± 4.63

7.31 ± 4.35

Il-1β (ng/mL)

3.65 ± 1.63

3.71 ± 1.98

3.93 ± 2.95

3.52 ± 2.07

3.78 ± 2.26

4.02 ± 1.99

3.65 ± 2.62

4.83 ± 1.59

hs-CRP (mg/L)

4.45 ± 1.51

3.24 ± 1.96*

4.90 ± 1.98

3.01 ± 1.77*

4.86 ± 1.70

2.23 ± 1.57*a

4.67 ± 1.37

4.11 ± 1.18

SOD (kU/L)

72.62 ± 18.56

76.36 ± 20.26*

76.32 ± 20.21

80.55 ± 25.27△

74.98 ± 19.50

79.24 ± 23.70△a

75.46 ± 21.56

78.68 ± 22.33△

MDA (μmol/L)

6.03 ± 1.42

4.28 ± 1.94*

6.94 ± 1.68

5.22 ± 1.73*

6.53 ± 1.25

4.98 ± 1.56*

6.14 ± 1.88

4.38 ± 1.62*

8-iso-PGF2α (μg/L)

10.35 ± 4.44

8.87 ± 5.91*

12.11 ± 7.66

7.65 ± 7.15*

11.30 ± 6.80

7.22 ± 6.31*a

10.87 ± 6.83

8.94 ± 6.34*

TAC (kU/L)

24.62 ± 10.69

27.30 ± 12.35*

25.31 ± 12.24

28.97 ± 9.18*

23.66 ± 11.01

27.00 ± 10.82*

24.48 ± 12.47

28.83 ± 10.82*

  1. P < 0.05, compared with the baseline level
  2. ∆P < 0.01, compared with the baseline level
  3. aP < 0.05, compared with the RSG group after treatment