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Table 1 Physiological parameters of STZ-diabetic rats treated with curcumin alone or combined with metformin

From: Curcumin combined with metformin decreases glycemia and dyslipidemia, and increases paraoxonase activity in diabetic rats

 

Groups

NYOG

DYOG

DINS

DC90

DM250

DC90M250

Day 0

Day 30

Day 0

Day 30

Day 0

Day 30

Day 0

Day 30

Day 0

Day 30

Day 0

Day 30

Body weight (g)

175.80 ± 9.34

332.60 ± 18.82#

173.91 ± 3.83

237.08 ± 19.65a,#

175.38 ± 4.86

323.13 ± 6.58b,#

172.07 ± 2.79

268.42 ± 7.90a,c,#

171.06 ± 7.53

267.13 ± 8.97a,c,#

173.50 ± 5.08

298.53 ± 9.19b,#

Food intake (g/24 h)

20.42 ± 1.59

20.25 ± 2.71

26.31 ± 2.12

41.75 ± 2.06a,#

26.83 ± 1.57

22.79 ± 1.05b

26.33 ± 1.99

33.21 ± 4.43a,#

26.75 ± 1.44

32.64 ± 3.69a,#

26.50 ± 1.68

28.00 ± 4.11b

Water intake (mL/24 h)

30.17 ± 2.76

26.08 ± 2.28

89.20 ± 12.14

188.33 ± 13.12a,#

85.21 ± 13.40

25.78 ± 2.61b,#

85.14 ± 7.20

125.67 ± 25.18a,b,c,#

86.29 ± 6.73

89.22 ± 5.40a,b,c

81.25 ± 7.21

85.31 ± 8.97a,b,c

Urinary volume (mL/24 h)

5.42 ± 0.29

16.50 ± 1.31#

62.80 ± 10.17

165.17 ± 11.55a,#

66.40 ± 9.37

18.50 ± 3.57b,#

61.86 ± 6.34

122.67 ± 16.28a,b,c,#

63.04 ± 8.67

80.00 ± 11.57a,b,c

61.50 ± 10.11

80.60 ± 10.45a,b,c

Glycosuria (g/24 h)

nd

nd

1.92 ± 0.53

11.06 ± 0.78#

2.52 ± 0.64

0.19 ± 0.041b,#

2.58 ± 0.78

2.82 ± 0.67b,c

2.21 ± 0.12

2.78 ± 0.13b,c

2.31 ± 0.13

2.78 ± 0.19b,c

  1. Values are expressed as mean ± SEM, n = 10
  2. The differences between groups were considered significant at p < 0.05 and were analyzed using one-way ANOVA followed by Student–Newman–Keuls test
  3. nd, not determined; NYOG, normal rats treated with yoghurt; DYOG, diabetic rats treated with yoghurt; DINS, diabetic rats treated with 4 U/day insulin; DC90, diabetic rats treated with 90 mg/kg curcumin in yoghurt; DM250, diabetic rats treated with 250 mg/kg metformin in yoghurt; DC90M250, diabetic rats treated with 90 mg/kg curcumin + 250 mg/kg metformin in yoghurt
  4. aDifferences with NYOG; b differences with DYOG; c differences with DINS. Differences compared in the same group relative to day 0 were analyzed using the paired Student’s t-test. # Differences with day 0 (p < 0.05)