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Table 3 Urinary proteins identified with MALDI-QTOF

From: Characterization of low molecular weight urinary proteins at varying time intervals in type 2 diabetes mellitus and diabetic nephropathy patients

Spot no Accession no Protein name MW (kDa) pI Protein/peptide excreted during Classification of LMWPs depending upon its early excretion
1, 3, 9 P02766 Transthyretin/prealbumin 15.88 5.69 0–5, 5–10 and 10–15 years of T2DM Group 1: LMWPs excreting in early years i.e. 0–5 and 5–10 years T2DM
2, 4, 13, 24, 32 P01834 Ig kappa C chain region 16.60 5.58 0–5, 5–10, 15–20 years of T2DM, MIA and DN
5, 11, 16, 26, 27, 37 P01034 Cystatin C 15.79 9.00 5–10, 10–15, 15–20 years of T2DM, MIA and DN
6, 12, 17, 28, 29, 38 P62979 Ubiquitin 17.96 9.00 5–10, 10–15, 15–20 years of T2DM, MIA and DN
7, 8, 18, 19 P02763 Alpha 1 acid glycoprotein 1 23.51 4.93 10–15 years of T2DM and MIA Group 2: LMWPs excreting in later years i.e. 10–15 and 15–20 years T2DM
10 P02647 Apolipoprotein A1 30.77 5.56 10–15 years of T2DM
14 P25311 Zinc alpha 2 glycoprotein 37.25 5.71 15–20 years of T2DM
15, 33 P02760 Alpha 1 microglobulin/bikunin precursor 35.99 5.95 15–20 years of T2DM and DN
20, 21 P06727 Apolipoprotein A IV 45.39 5.28 MIA Group 3: LMWPs excreting in advanced stages i.e. MIA and DN
22, 23, 31 P01009 Alpha 1 antitrypsin 46.73 5.37 MIA, DN
25 P00738 Haptoglobin 45.20 6.13 MIA
30 P01614 Ig kappa chain V–II 12.67 5.28 DN
34, 35 Q86WR0 Protein 25 24.47 6.34 DN
36 P0CG05 Ig lambda 2 chain region 11.29 6.91 DN
  1. Proteins were recognized using NCBI and SWISS PROT database of urine. The molecular weight and pI of the protein were calculated using ProtParam ExPASY tool