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Table 1 Baseline characteristics as a function of the median of adiponectin levels

From: Serum concentration and vascular expression of adiponectin are differentially associated with the diabetic calcifying peripheral arteriopathy

 

All

n = 197

Adiponectin

< 3.5 µg/mL

n = 98

Adiponectin

≥ 3.5 µg/mL

n = 99

P

Adiponectin (µg/mL)

4.1 ± 2.6 (3.5)

2.5 ± 0.6 (2.6)

5.7 ± 2.8 (5.0)

NA

Age (years)

64 ± 8

62 ± 9

67 ± 8

< 0.0001

Diabetes duration (years)

15 ± 10

14 ± 9

15 ± 9

0.322

Male gender n (%)

157 (80)

86 (88)

71 (72)

0.007

Body mass index (kg/m2)

29 ± 5

29 ±5

29 ± 6

0.441

SBP (mmHg)

127 ± 17

125 ± 17

129 ± 17

0.123

DBP (mmHg)

73 ± 9

73 ± 9

73 ± 9

0.472

Smoking habit n (%)

118 (60)

69 (70)

49 (50)

0.004

Previous CVD n (%)

138 (70)

71 (72)

67 (68)

0.534

Glycaemia (mmol/L)

8.2 ± 2.8 (7.8)

8.3 ± 2.8 (7.8)

8.0 ± 2.8 (7.4)

0.391

HbA1c (%)

7.8 ± 1.5 (7.5)

7.8 ± 1.4 (7.7)

7.7 ± 1.5 (7.4)

0.408

GFR MDRD (mmol/L)

76 ± 20

80 ± 19

72 ± 20

0.003

Microalbuminuria (mg/L)

166 ± 842 (23)

100 ± 322 (20)

230 ± 1144 (23)

0.328

Calcium (mmol/L)

2.30 ± 0.11

2.32 ± 0.09

2.32 ± 0.13

0.885

Phosphate (mmol/L)

1.02 ± 0.15

1.01 ± 0.15

1.04 ± 0.16

0.165

Intact PTH (pg/mL)

54.7 ± 27.5 (46.9)

48.8 ± 24.7 (42.9

60.6 ± 29.0 (54.0)

0.001

25(OH)Vit D (ng/mL)

13.8 ± 8.4 (12.0)

14.0 ± 8.7 (12.0)

13.7 ± 8.1 (12.0)

0.924

hsCRP (mg/L)

2.2 ± 1.5 (1.2)

2.5 ± 2.6 (1.5)

1.9 ± 2.3 (0.8)

0.035

IL6 (pg/mL)

5 ± 22 (3)

7 ± 31 (3)

3.3 ± 3.9 (2.7)

0.045

Triglycerides (mmol/L)

1.6 ± 1.1 (1.3)

1.8 ± 1.2 (1.4)

1.4 ± 0.8 (1.1)

0.001

Total cholesterol (mmol/L)

3.7 ± 0.9

3.6 ± 0.9

3.8 ± 0.9

0.146

LDL cholesterol (mmol/L)

1.9 ± 0.7 (1.8)

1.9 ± 0.7 (1.8)

2.0 ± 0.8 (1.8)

0.097

Total cholesterol/HDL cholesterol

3.7 ± 1.6 (3.5)

4.1 ± 1.9 (3.7)

3.4 ± 1.0 (3.3)

< 0.0001

NDS

2.4 ± 2.4 (2.4)

2.1 ± 2.4 (2)

2.7 ± 2.4 (2)

0.035

Peripheral calcification score

2528 ± 5779 (524)

1818 ± 5283 (290)

3239 ± 6204 (1044)

0.004

Occlusive score

3.5 ± 5.3

2.8 ± 4.8

4.2 ± 5.7

0.034

Insulin use n (%)

93 (47)

45 (46)

48 (49)

0.414

Metformin use n (%)

160 (81)

88 (90)

72 (73)

0.002

Statin use n (%)

175 (89)

88 (90)

87 (88)

0.421

ARB and ACE inhibitors use n (%)

158 (80)

81 (83)

77 (78)

0.249

  1. Data are given as mean ± SD for normally distributed measures with addition of (median) for non-normally distributed values for variables with a non-Gaussian distribution or as the number (percentage) for binary variables; variables mentioned in italic are variables distributed significantly different in both groups
  2. NA not applicable, ARB angiotensin receptor blockers, ACE angiotensin converting enzyme, SBP systolic blood pressure, DBP diastolic blood pressure, CVD cardiovascular disease, HbA1c haemoglobin A1C, GFR MDRD glomerular filtration rate calculated with the modification of diet in renal disease formula, PTH parathyroid hormone, hsCRP high sensibility C-reactive protein, IL-6 interleukin 6, NDS neuropathy disability score
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Diabetology & Metabolic Syndrome

ISSN: 1758-5996

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